PMID- 15884004
OWN - NLM
STAT- MEDLINE
DCOM- 20050822
LR  - 20071114
IS  - 0022-3034 (Print)
IS  - 0022-3034 (Linking)
VI  - 64
IP  - 1
DP  - 2005 Jul
TI  - Gonadal hormone modulation of dendrites in the mammalian CNS.
PG  - 34-46
AB  - This review focuses on the effect of gonadal steroid hormones, androgen and 
      estrogen, on dendrites in the adult rat central nervous system (CNS). Four 
      hormone-responsive nuclei are considered: The spinal nucleus of the 
      bulbocavernosus (SNB), the medial nucleus of the amygdala (MeA), the ventromedial 
      nucleus of the hypothalamus (VMN), and the CA1 region of the dorsal hippocampus. 
      Particular emphasis is placed on the mode of hormone action in each nucleus. In 
      the SNB, VMN, and hippocampus, hormones appear to mediate their effects 
      indirectly, via cells other than those that display morphological plasticity. In 
      the MeA, estrogen and/or androgen appears to act primarily on those cells whose 
      dendrites are modulated by the hormone. Importantly, increasing levels of gonadal 
      hormones do not simply result in increases in dendritic parameters. In the VMN, 
      high levels of estrogen associated with proestrus increase dendritic spine 
      density in one subset of cells and reduce spine density in another subset. The 
      pyramidal cells of dorsal CA1 also undergo phasic changes in dendritic spine and 
      synapse density across the estrous cycle. The estrogen-induced excitatory 
      synapses connect with preexisting axonal boutons that also form synapses with 
      other CA1 cells, thereby increasing the divergence of excitatory afferents to 
      dorsal CA1. These findings indicate that gonadal steroids have a profound impact 
      on the morphology of dendrites and patterns of synaptic connectivity. 
      Consequently, the experimental manipulation of hormone levels is a powerful tool 
      to study structure-function relationships in the mammalian brain.
CI  - Copyright 2005 Wiley Periodicals, Inc.
FAU - Cooke, Bradley M
AU  - Cooke BM
AD  - Department of Neurobiology and Physiology, Northwestern University, Evanston, 
      Illinois 60208, USA. b-cooke@northwestern.edu
FAU - Woolley, Catherine S
AU  - Woolley CS
LA  - eng
GR  - NS37324/NS/NINDS NIH HHS/United States
GR  - T32 HD07068/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Neurobiol
JT  - Journal of neurobiology
JID - 0213640
RN  - 0 (Gonadal Hormones)
SB  - IM
MH  - Animals
MH  - Central Nervous System/*cytology
MH  - Dendrites/*physiology
MH  - Gonadal Hormones/*physiology
MH  - Maze Learning/physiology
MH  - Models, Biological
MH  - Neuronal Plasticity/physiology
MH  - Neurons/*cytology/physiology
MH  - Sex Characteristics
MH  - Time Factors
RF  - 86
EDAT- 2005/05/11 09:00
MHDA- 2005/08/23 09:00
CRDT- 2005/05/11 09:00
PHST- 2005/05/11 09:00 [pubmed]
PHST- 2005/08/23 09:00 [medline]
PHST- 2005/05/11 09:00 [entrez]
AID - 10.1002/neu.20143 [doi]
PST - ppublish
SO  - J Neurobiol. 2005 Jul;64(1):34-46. doi: 10.1002/neu.20143.