PMID- 15885081
OWN - NLM
STAT- MEDLINE
DCOM- 20050808
LR  - 20220311
IS  - 0906-6705 (Print)
IS  - 0906-6705 (Linking)
VI  - 14
IP  - 6
DP  - 2005 Jun
TI  - The expression of human leukocyte antigen-DR and CD25 on circulating T cells in 
      cutaneous lupus erythematosus and correlation with disease activity.
PG  - 454-9
AB  - BACKGROUND: Lupus erythematosus (LE) is a chronic autoimmune disease with a broad 
      clinical spectrum reaching from primarily cutaneous manifestations [cutaneous LE 
      (CLE)] up to systemic disease [systemic LE (SLE)]. In patients with SLE, the 
      expression of activation markers on circulating T cells reflects disease 
      activity. Here, we investigated whether this also holds true for patients with 
      CLE. PATIENTS AND METHODS: The expression of the activation markers human 
      leukocyte antigen (HLA)-DR and CD25 on circulating T lymphocytes was measured by 
      flow cytometry in 24 patients suffering from different types of active CLE. 
      Simultaneously, the disease activity was assessed clinically using a CLE activity 
      index. Eighteen healthy donors were analyzed for control purposes. RESULTS: 
      HLA-DR was expressed on a significantly elevated percentage of both CD4+ and CD8+ 
      circulating T cells in active CLE patients when compared with healthy controls. 
      The percentage of HLA-DR-expressing T lymphocytes closely correlated with the 
      disease activity. Interestingly, in disseminated scarring chronic discoid LE, a 
      significantly increased percentage of CD25+ cells was observed only in the subset 
      of skin-homing cutaneous lymphocyte antigen (CLA)+CD4+ and CD8+ T cells. 
      CONCLUSION: Our results provide evidence that activation markers on peripheral 
      blood T cells might help to objectively assess the disease activity in CLE. 
      Furthermore, a significant population of CD25+CLA+CD8+ T cells can only be 
      detected in a subgroup of patients with disseminated scarring CLE and might 
      reflect the systemic expansion of activated cytotoxic T lymphocytes involved in 
      destruction of epidermal tissue.
FAU - Wenzel, Joerg
AU  - Wenzel J
AD  - Department of Dermatology, University of Bonn, Bonn, Germany. 
      joerg.wenzel@ukb.uni-bonn.de
FAU - Henze, Stephanie
AU  - Henze S
FAU - Brahler, Sabine
AU  - Brahler S
FAU - Bieber, Thomas
AU  - Bieber T
FAU - Tuting, Thomas
AU  - Tuting T
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - CD4-Positive T-Lymphocytes/metabolism
MH  - CD8-Positive T-Lymphocytes/metabolism
MH  - Epidermis/metabolism
MH  - Flow Cytometry
MH  - HLA-DR Antigens/*biosynthesis
MH  - Humans
MH  - Inflammation
MH  - Lupus Erythematosus, Cutaneous/*blood/*metabolism/pathology
MH  - Receptors, Interleukin-2/*biosynthesis
MH  - T-Lymphocytes/*metabolism
EDAT- 2005/05/12 09:00
MHDA- 2005/08/09 09:00
CRDT- 2005/05/12 09:00
PHST- 2005/05/12 09:00 [pubmed]
PHST- 2005/08/09 09:00 [medline]
PHST- 2005/05/12 09:00 [entrez]
AID - EXD301 [pii]
AID - 10.1111/j.0906-6705.2005.00301.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2005 Jun;14(6):454-9. doi: 10.1111/j.0906-6705.2005.00301.x.