PMID- 15885249
OWN - NLM
STAT- MEDLINE
DCOM- 20050624
LR  - 20061115
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 84
IP  - 5
DP  - 2005 Apr 13
TI  - Long-term treadmill exercise overcomes ischemia-induced apoptotic neuronal cell 
      death in gerbils.
PG  - 733-8
AB  - It has been suggested that exercise may ameliorate neurologic impairment by 
      impeding neuronal loss following various brain insults. In the present study, the 
      effect of long-term treadmill exercise on short-term memory and apoptotic 
      neuronal cell death in the hippocampus following transient global ischemia in 
      gerbils was investigated. A step-down inhibitory avoidance task, terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, and 
      immunohistochemistry for caspase-3 were used for this study. Ischemia was induced 
      by occlusion of both the common carotid arteries of gerbils for 5 min. Gerbils in 
      the exercise groups were forced to run on a treadmill for 30 min once a day for 4 
      consecutive weeks. The present results reveal that treadmill exercise for 4 weeks 
      improved short-term memory by suppressing the ischemia-induced apoptotic neuronal 
      cell death in the hippocampus. Here in this study, we show that long-term 
      treadmill exercise for 4 weeks overcomes the ischemia-induced apoptotic neuronal 
      cell death and thus facilitates the recovery of short-term memory impairment 
      induced by ischemic cerebral injury.
FAU - Sim, Young-Je
AU  - Sim YJ
AD  - Department of Exercise Physiology, Graduate School, Korea University, #1 5-Ka 
      Anam-dong, Sungbuk-gu, Seoul 136-701, Republic of Korea.
FAU - Kim, Hong
AU  - Kim H
FAU - Kim, Jee-Youn
AU  - Kim JY
FAU - Yoon, Sung-Jin
AU  - Yoon SJ
FAU - Kim, Sung-Soo
AU  - Kim SS
FAU - Chang, Hyun-Kyung
AU  - Chang HK
FAU - Lee, Taeck-Hyun
AU  - Lee TH
FAU - Lee, Hee-Hyuk
AU  - Lee HH
FAU - Shin, Min-Chul
AU  - Shin MC
FAU - Shin, Mal-Soon
AU  - Shin MS
FAU - Kim, Chang-Ju
AU  - Kim CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050329
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Avoidance Learning/physiology
MH  - Caspase 3
MH  - Caspases/metabolism
MH  - DNA Fragmentation
MH  - Dentate Gyrus/pathology/physiology
MH  - Gerbillinae
MH  - Hippocampus/pathology/physiology
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Ischemic Attack, Transient/*pathology
MH  - Male
MH  - Neurons/*pathology/*physiology
MH  - Physical Conditioning, Animal/*physiology
EDAT- 2005/05/12 09:00
MHDA- 2005/06/25 09:00
CRDT- 2005/05/12 09:00
PHST- 2004/08/03 00:00 [received]
PHST- 2005/01/26 00:00 [revised]
PHST- 2005/02/23 00:00 [accepted]
PHST- 2005/05/12 09:00 [pubmed]
PHST- 2005/06/25 09:00 [medline]
PHST- 2005/05/12 09:00 [entrez]
AID - S0031-9384(05)00072-7 [pii]
AID - 10.1016/j.physbeh.2005.02.019 [doi]
PST - ppublish
SO  - Physiol Behav. 2005 Apr 13;84(5):733-8. doi: 10.1016/j.physbeh.2005.02.019. Epub 
      2005 Mar 29.