PMID- 15885251
OWN - NLM
STAT- MEDLINE
DCOM- 20050624
LR  - 20141120
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 84
IP  - 5
DP  - 2005 Apr 13
TI  - Early postnatal ethanol administration does not affect prepulse inhibition in 
      rats.
PG  - 747-52
AB  - Human prenatal ethanol exposure is associated with relatively widespread 
      cognitive deficits but it is unclear whether general deficits in responsivity to 
      sensory stimuli contribute to or underlie the deficits in later or more complex 
      stages of information processing. The present experiment assessed the effects of 
      early postnatal ethanol administration in rats on prepulse inhibition, with 
      animals tested in adolescence (postnatal day (PD) 35) and early adulthood (PD 
      70). Animals were assigned to receive ethanol (5.25 g/kg) via intragastric 
      intubation on PD 4-9, sham-intubation, or to a naive control group. Pre-exposure 
      to ethanol did not differentially affect the magnitude of the response to the 
      startle stimulus alone nor did it affect the percent inhibition of the startle 
      response on trials with a prepulse stimulus. Male rats exhibited a greater 
      percent inhibition than female rats on PD 35 at all interstimulus intervals 
      (ISIs) except the shortest, 4 ms. Female rats exhibited a greater percent 
      inhibition than male rats at all ISIs on PD 70. Collectively, these data 
      demonstrate that cognitive deficits associated with early exposure to ethanol may 
      not be attributable to deficits in sensorimotor gating, at least to the extent 
      this construct is measured by prepulse inhibition.
FAU - Woolfrey, Kevin M
AU  - Woolfrey KM
AD  - Department of Psychology, College of William and Mary, P.O. Box 8795, 
      Williamsburg, VA 23187-8795, USA.
FAU - Musisca, Nicholas J
AU  - Musisca NJ
FAU - Hunt, Pamela S
AU  - Hunt PS
FAU - Burk, Joshua A
AU  - Burk JA
LA  - eng
GR  - AA12466/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050413
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*physiology
MH  - Body Weight/drug effects
MH  - Central Nervous System Depressants/administration & dosage/*pharmacology
MH  - Ethanol/administration & dosage/*pharmacology
MH  - Female
MH  - Injections, Intravenous
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reflex, Startle/*drug effects
EDAT- 2005/05/12 09:00
MHDA- 2005/06/25 09:00
CRDT- 2005/05/12 09:00
PHST- 2004/07/30 00:00 [received]
PHST- 2004/11/14 00:00 [revised]
PHST- 2005/03/02 00:00 [accepted]
PHST- 2005/05/12 09:00 [pubmed]
PHST- 2005/06/25 09:00 [medline]
PHST- 2005/05/12 09:00 [entrez]
AID - S0031-9384(05)00079-X [pii]
AID - 10.1016/j.physbeh.2005.03.003 [doi]
PST - ppublish
SO  - Physiol Behav. 2005 Apr 13;84(5):747-52. doi: 10.1016/j.physbeh.2005.03.003. Epub 
      2005 Apr 13.