PMID- 15887243 OWN - NLM STAT- MEDLINE DCOM- 20050920 LR - 20231213 IS - 1045-2257 (Print) IS - 1045-2257 (Linking) VI - 44 IP - 1 DP - 2005 Sep TI - ETV6 gene rearrangements in invasive breast carcinoma. PG - 103-8 AB - The ETV6/TEL gene encodes a transcription factor frequently rearranged in several types of cancer. We looked for ETV6 rearrangements in invasive breast cancer using fluorescence in situ hybridization (FISH) of BAC probes on sections of tissue microarrays containing 632 tumor samples. Of these samples, signal of sufficient quality for screening by FISH was obtained for 356. Five cases (one lobular, one nontypical secretory, one mixed, and two ductal carcinomas) showed ETV6 rearrangement. CI - (c) 2005 Wiley-Liss, Inc. FAU - Letessier, Anne AU - Letessier A AD - Marseille Cancer Institute, Laboratory of Molecular Oncology, Institut Paoli-Calmettes and UMR599 Inserm, Marseille, France. FAU - Ginestier, Christophe AU - Ginestier C FAU - Charafe-Jauffret, Emmanuelle AU - Charafe-Jauffret E FAU - Cervera, Nathalie AU - Cervera N FAU - Adelaide, Jose AU - Adelaide J FAU - Gelsi-Boyer, Veronique AU - Gelsi-Boyer V FAU - Ahomadegbe, Jean-Charles AU - Ahomadegbe JC FAU - Benard, Jean AU - Benard J FAU - Jacquemier, Jocelyne AU - Jacquemier J FAU - Birnbaum, Daniel AU - Birnbaum D FAU - Chaffanet, Max AU - Chaffanet M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Genes Chromosomes Cancer JT - Genes, chromosomes & cancer JID - 9007329 RN - 0 (DNA-Binding Proteins) RN - 0 (Nuclear Proteins) RN - 0 (Proto-Oncogene Proteins c-ets) RN - 0 (Repressor Proteins) SB - IM MH - Adenocarcinoma/genetics MH - Adult MH - Aged MH - Aged, 80 and over MH - Artificial Gene Fusion MH - Breast Neoplasms/*genetics/pathology MH - Centromere/genetics MH - Chromosome Mapping MH - DNA-Binding Proteins/*genetics MH - Female MH - Gene Rearrangement MH - Humans MH - In Situ Hybridization, Fluorescence MH - Middle Aged MH - Neoplasm Invasiveness MH - Nuclear Proteins/*genetics MH - Proto-Oncogene Proteins c-ets MH - Repressor Proteins/*genetics MH - Telomere/genetics MH - ETS Translocation Variant 6 Protein EDAT- 2005/05/12 09:00 MHDA- 2005/09/21 09:00 CRDT- 2005/05/12 09:00 PHST- 2005/05/12 09:00 [pubmed] PHST- 2005/09/21 09:00 [medline] PHST- 2005/05/12 09:00 [entrez] AID - 10.1002/gcc.20200 [doi] PST - ppublish SO - Genes Chromosomes Cancer. 2005 Sep;44(1):103-8. doi: 10.1002/gcc.20200.