PMID- 15887626
OWN - NLM
STAT- MEDLINE
DCOM- 20050726
LR  - 20050512
IS  - 0394-3402 (Print)
IS  - 0394-3402 (Linking)
VI  - 17
IP  - 6
DP  - 2004 Dec
TI  - The relationship between levels of alpha1-acid glycoprotein and metabolic 
      parameters of diabetes mellitus.
PG  - 331-5
AB  - The aim of this study was to investigate the relationship of alpha1-acid 
      glycoprotein (AGP, orosomucoid), which is an acute-phase reactant, in patients 
      with Type 1 (T1DM) and Type 2 diabetes mellitus (T2DM), with the metabolic 
      parameters and complications of diabetes mellitus. A total of 119 diabetic 
      patients (89 T2DM, 30 T1DM) and 33 healthy controls were included in the study. 
      The mean AGP level in the diabetic group was not different from the control group 
      (82.4 +/- 28.9 and 81.6 +/- 16.6 mg/dl, respectively), but it was higher in T2DM 
      than in T1DM subjects (86.6 +/- 28.3 and 69.7 +/- 26.9, respectively). AGP plasma 
      levels showed a significant correlation with age and body mass index (r = +0.348 
      and r = +0.296, respectively). AGP plasma levels resulted higher in obese 
      diabetic patients (97.7 +/- 28.0) than in non-obese diabetic patients (77.6 +/- 
      28.7 mg/dl) and controls (81.6 +/- 16.6), and also higher in diabetic subjects 
      with poor glycaemic control (85.1 +/- 33.3 mg/dl) than in diabetic subjects with 
      optimal glycaemic control (79.5 +/- 23.1 mg/dl). A relationship between AGP and 
      macro- and microvascular complications of diabetes mellitus was not found. In 
      conclusion, inflammatory findings were more prominent in obese diabetic patients.
FAU - Akbay, E
AU  - Akbay E
AD  - Department of Endocrinology and Metabolism, Mersin University, Mersin, Turkey. 
      eakbay@mersin.edu.tr
FAU - Yetkin, I
AU  - Yetkin I
FAU - Ersoy, R
AU  - Ersoy R
FAU - Kulaksizoglu, S
AU  - Kulaksizoglu S
FAU - Toruner, F
AU  - Toruner F
FAU - Arslan, M
AU  - Arslan M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Diabetes Nutr Metab
JT  - Diabetes, nutrition & metabolism
JID - 8813443
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Blood Glucose)
RN  - 0 (Orosomucoid)
SB  - IM
MH  - Acute-Phase Proteins/analysis
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aging
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 1/*blood/complications
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Diabetic Angiopathies/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood
MH  - Orosomucoid/*analysis
EDAT- 2005/05/13 09:00
MHDA- 2005/07/27 09:00
CRDT- 2005/05/13 09:00
PHST- 2005/05/13 09:00 [pubmed]
PHST- 2005/07/27 09:00 [medline]
PHST- 2005/05/13 09:00 [entrez]
PST - ppublish
SO  - Diabetes Nutr Metab. 2004 Dec;17(6):331-5.