PMID- 15890493
OWN - NLM
STAT- MEDLINE
DCOM- 20060206
LR  - 20181113
IS  - 0889-1591 (Print)
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 19
IP  - 6
DP  - 2005 Nov
TI  - TNF-alpha levels in cancer patients relate to social variables.
PG  - 521-5
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an important cytokine associated with 
      tumor regression and increased survival time for cancer patients. Research 
      evidence relates immune factors (e.g., natural killer (NK) cell counts, NK cell 
      lysis, lymphocyte profile, and lymphocyte proliferation) to the frequency and 
      quality of social relations among cancer patients. We hypothesized that 
      disruptions in social relations would be associated with lower TNF-alpha 
      responses, and conversely, that reports of positive changes in social relations 
      correlate with stronger responses. A prospective design measured changes in 
      social activity and relationship satisfaction with a partner in 44 breast cancer 
      patients at the time of cancer diagnosis, and initial surgery and 12 months 
      later. Results indicated that patients reporting increased social activities or 
      satisfaction exhibited stronger stimulated TNF-alpha responses. This is the first 
      study to link changes in patient social relations with a cancer-relevant immune 
      variable.
FAU - Marucha, Phillip T
AU  - Marucha PT
AD  - Department of Periodontics, College of Dentistry, University of Illinois at 
      Chicago, USA.
FAU - Crespin, Timothy R
AU  - Crespin TR
FAU - Shelby, Rebecca A
AU  - Shelby RA
FAU - Andersen, Barbara L
AU  - Andersen BL
LA  - eng
GR  - M01-RR0034/RR/NCRR NIH HHS/United States
GR  - U10 CA077658/CA/NCI NIH HHS/United States
GR  - U01 CA77658/CA/NCI NIH HHS/United States
GR  - M01 RR000034/RR/NCRR NIH HHS/United States
GR  - K05 CA098133/CA/NCI NIH HHS/United States
GR  - P30 CA016058-319029/CA/NCI NIH HHS/United States
GR  - R01 CA92704/CA/NCI NIH HHS/United States
GR  - M01 RR000034-460772/RR/NCRR NIH HHS/United States
GR  - R01 CA092704/CA/NCI NIH HHS/United States
GR  - P30 CA16058/CA/NCI NIH HHS/United States
GR  - P30 CA016058/CA/NCI NIH HHS/United States
GR  - R01 MH051487/MH/NIMH NIH HHS/United States
GR  - R01 MH051487-05/MH/NIMH NIH HHS/United States
GR  - R01 MH51487/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adaptation, Psychological/physiology
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/blood/*immunology/*psychology
MH  - Female
MH  - Humans
MH  - Leisure Activities/psychology
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Psychoneuroimmunology
MH  - Regression Analysis
MH  - *Social Adjustment
MH  - Social Environment
MH  - *Social Support
MH  - Stress, Psychological/immunology
MH  - Tumor Necrosis Factor-alpha/*analysis
PMC - PMC2170527
MID - NIHMS70062
EDAT- 2005/05/14 09:00
MHDA- 2006/02/07 09:00
PMCR- 2008/10/06
CRDT- 2005/05/14 09:00
PHST- 2004/08/24 00:00 [received]
PHST- 2005/01/26 00:00 [revised]
PHST- 2005/03/27 00:00 [accepted]
PHST- 2005/05/14 09:00 [pubmed]
PHST- 2006/02/07 09:00 [medline]
PHST- 2005/05/14 09:00 [entrez]
PHST- 2008/10/06 00:00 [pmc-release]
AID - S0889-1591(05)00065-6 [pii]
AID - 10.1016/j.bbi.2005.03.014 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2005 Nov;19(6):521-5. doi: 10.1016/j.bbi.2005.03.014.