PMID- 15891264
OWN - NLM
STAT- MEDLINE
DCOM- 20050803
LR  - 20071115
IS  - 1075-2765 (Print)
IS  - 1075-2765 (Linking)
VI  - 12
IP  - 3
DP  - 2005 May-Jun
TI  - The effect of magnesium sulfate on action potential duration and cardiac 
      arrhythmias.
PG  - 218-22
AB  - To evaluate the electrophysiologic and antiarrhythmic effects, Mg was infused at 
      15 mg/h (n = 5) or an equal volume of saline (1.2 mL/h) (n = 5) and 
      electrocardiogram and action potential duration (APD) recorded every 15 minutes. 
      Rats were anesthetized with 70 mg/kg pentobarbital intraperitoneally. Mg 
      increased QT 15 +/- 6% on average compared with 1 +/- 4 for saline P < 0.01. Mg 
      increased QT, 0, 0, 6 +/- 4, 13 +/- 5, 16 +/- 4, 23 +/- 5, 29 +/- 8, and 32 +/- 
      5% over baseline after a 2 hours infusion (P < 0.01). APD increased by 0, 6 +/- 
      3, 8 +/- 8, 14 +/- 4, 16 +/- 12, 21 +/- 4, 25 +/- 5% change from baseline (P < 
      0.05). The mean percentage of increase was 12 +/- 8 for the Mg group and 1 +/- 3 
      for the saline group (P < 0.05). The JT interval also increased after Mg (P < 
      0.01). After Mg loading, coronary occlusion of the left anterior descending 
      coronary artery was performed. Ventricular premature contractions (VPCs), 
      ventricular tachycardia (VT), and ventricular fibrillation (VF) were frequent in 
      the saline control group, with 2 dying in VF; with only scattered VPCs and short 
      runs of nonsustained VT in the Mg group. The results of these findings indicate 
      that infusion of MgSO4 can prolong the QRS, QT, and JT intervals in the rat and 
      these changes correlate well with arrhythmia suppression.
FAU - Somberg, John C
AU  - Somberg JC
AD  - Division of Clinical Pharmacology, Rush University, Chicago, Illinois, USA. 
      jsomberg@rush.edu
FAU - Cao, Wei
AU  - Cao W
FAU - Cvetanovic, Ivana
AU  - Cvetanovic I
FAU - Ranade, Vasant V
AU  - Ranade VV
FAU - Molnar, Janos
AU  - Molnar J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Ther
JT  - American journal of therapeutics
JID - 9441347
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 7487-88-9 (Magnesium Sulfate)
SB  - IM
MH  - Action Potentials/*drug effects
MH  - Animals
MH  - Anti-Arrhythmia Agents/*therapeutic use
MH  - Arrhythmias, Cardiac/*drug therapy/physiopathology
MH  - Electrocardiography
MH  - Magnesium Sulfate/*therapeutic use
MH  - Rats
EDAT- 2005/05/14 09:00
MHDA- 2005/08/04 09:00
CRDT- 2005/05/14 09:00
PHST- 2005/05/14 09:00 [pubmed]
PHST- 2005/08/04 09:00 [medline]
PHST- 2005/05/14 09:00 [entrez]
AID - 00045391-200505000-00004 [pii]
PST - ppublish
SO  - Am J Ther. 2005 May-Jun;12(3):218-22.