PMID- 15892087
OWN - NLM
STAT- MEDLINE
DCOM- 20051221
LR  - 20061115
IS  - 0733-2459 (Print)
IS  - 0733-2459 (Linking)
VI  - 20
IP  - 3
DP  - 2005 Oct
TI  - Reduced oxidative stress in parallel to improved cardiac performance one year 
      after selective removal of anti-beta 1-adrenoreceptor autoantibodies in patients 
      with idiopathic dilated cardiomyopathy: data of a preliminary study.
PG  - 137-42
AB  - Patients with idiopathic dilated cardiomyopathy (IDC) were treated with selective 
      immunoadsorption to remove anti-beta 1-adrenoreceptor autoantibodies 
      (anti-beta1A-AB). After one year, the effect on cardiac performance and oxidative 
      stress was tested. Extracorporeal immunoadsorption of the whole IgG class in IDC 
      patients for the removal of anti-beta1A-AB reduced oxidative stress in parallel 
      to an improvement of cardiac performance. However, the non-specificity of IgG 
      adsorption means that these beneficial effects cannot be attributed exclusively 
      to anti-beta1A-AB removal. In an open clinical pilot study enrolling 8 patients 
      with IDC prior to and one year after selective immunoadsorption of 
      anti-beta1A-AB, plasma markers for oxidative stress--thiobarbituric acid-reactive 
      substances (TBARS), lipid peroxides (LPO) and anti-oxidized low-density 
      lipoprotein autoantibodies (anti-oxLDL-AB)--were measured in parallel to 
      evaluation of the left ventricular function using conventional echocardiography 
      and wall motion analysis by tissue Doppler imaging. After one year, TBARS 
      (Wilcoxon test with bootstrapping simulation for paired data: 95% confidence 
      interval of the P value 0.020 to 0.029) and anti-oxLDL-AB (P = 0.025 to 0.035) 
      were decreased in parallel to an improvement of the peak systolic wall motion 
      velocity (P = 0.006 to 0.01) and left ventricular ejection fraction (P = 0.002 to 
      0.02). For changes over the study period, a direct correlation with borderline 
      significance (P = 0.076) was calculated for TBARS to the left ventricular 
      diameter in the diastole. One year after selective immunoadsorption for 
      anti-beta1A-AB removal, patients with ICD show a reduction in oxidative stress 
      and a parallel improvement in cardiac performance.
CI  - Copyright 2005 Wiley-Liss, Inc
FAU - Schimke, Ingolf
AU  - Schimke I
AD  - Medizinische Klinik (Kardiologie), Humboldt-Universitat zu Berlin, Berlin, 
      Germany. ingolf.schimke@charite.de
FAU - Muller, Johannes
AU  - Muller J
FAU - Dandel, Michael
AU  - Dandel M
FAU - Gremmels, Heinz-Detlef
AU  - Gremmels HD
FAU - Bayer, Wolfgang
AU  - Bayer W
FAU - Wallukat, Barbara
AU  - Wallukat B
FAU - Wallukat, Gerd
AU  - Wallukat G
FAU - Hetzer, Roland
AU  - Hetzer R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Apher
JT  - Journal of clinical apheresis
JID - 8216305
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Adrenergic, beta-1)
SB  - IM
MH  - Adsorption
MH  - Adult
MH  - *Autoantibodies/blood/immunology
MH  - Cardiomyopathy, Dilated/blood/immunology/*therapy
MH  - Female
MH  - *Hemodiafiltration/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Pilot Projects
MH  - *Receptors, Adrenergic, beta-1/blood/immunology
MH  - *Recovery of Function
MH  - Ventricular Function, Left
EDAT- 2005/05/14 09:00
MHDA- 2005/12/22 09:00
CRDT- 2005/05/14 09:00
PHST- 2005/05/14 09:00 [pubmed]
PHST- 2005/12/22 09:00 [medline]
PHST- 2005/05/14 09:00 [entrez]
AID - 10.1002/jca.20050 [doi]
PST - ppublish
SO  - J Clin Apher. 2005 Oct;20(3):137-42. doi: 10.1002/jca.20050.