PMID- 15893705
OWN - NLM
STAT- MEDLINE
DCOM- 20050729
LR  - 20141120
IS  - 1566-0702 (Print)
IS  - 1566-0702 (Linking)
VI  - 119
IP  - 1
DP  - 2005 Apr 29
TI  - Different modulation of spontaneous activities by nitrergic inhibitory nerves 
      between ileum and jejunum in W/Wv mutant mice.
PG  - 25-35
AB  - We compared the spontaneous electrical and mechanical activities between the 
      jejunum and ileum in the W/Wv mutant mouse, where ICC in the myenteric region 
      (ICC-MY) are deficient. Electrical slow waves (SWs) superimposed with spike 
      potentials, and synchronous circular and longitudinal muscle mechanical 
      activities at a regular rhythm under approximately 1 cm H2O were recorded in the 
      jejunum and ileum of wild-type mice. However, in the jejunum and ileum of W/Wv 
      mice, irregular electrical and mechanical activities without discernable SWs were 
      recorded. N-nitro-L-arginine methyl ester (L-NAME) significantly decreased the 
      mean interval of longitudinal muscle contractions from 4.43+/-3.39 to 2.50+/-1.23 
      s in the ileum of W/W(V) mice. L-NAME also significantly decreased mean 
      coefficient of variance (decreased irregularity) in the intervals from 
      2.59+/-0.84 to 0.48+/-0.46 in the ileum. Tetrodotoxin also significantly 
      decreased mean interval and coefficient of variance in the ileum. Neither L-NAME 
      nor tetrodotoxin affected contractile activity in the jejunum. These results 
      suggest that enteric nitrergic nerves in the ileum, but not the jejunum, mediate 
      a steady-state inhibition of myogenic activity in W/Wv mice.
FAU - Nakagawa, Tadashi
AU  - Nakagawa T
AD  - Department of Physiology II, Nara Medical University School of Medicine, 840 
      Shijo-cho, Kashihara, Nara 634-8521, Japan.
FAU - Ueshima, Shigeyuki
AU  - Ueshima S
FAU - Fujii, Hisao
AU  - Fujii H
FAU - Nakajima, Yoshiyuki
AU  - Nakajima Y
FAU - Takaki, Miyako
AU  - Takaki M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050323
PL  - Netherlands
TA  - Auton Neurosci
JT  - Autonomic neuroscience : basic & clinical
JID - 100909359
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Action Potentials/drug effects/*physiology
MH  - Animals
MH  - Ileum/drug effects/*physiology
MH  - In Vitro Techniques
MH  - Jejunum/drug effects/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Muscle Contraction/drug effects/physiology
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Neural Inhibition/drug effects/*physiology
MH  - Nitrergic Neurons/drug effects/*physiology
EDAT- 2005/05/17 09:00
MHDA- 2005/07/30 09:00
CRDT- 2005/05/17 09:00
PHST- 2005/01/07 00:00 [received]
PHST- 2005/01/07 00:00 [revised]
PHST- 2005/02/20 00:00 [accepted]
PHST- 2005/05/17 09:00 [pubmed]
PHST- 2005/07/30 09:00 [medline]
PHST- 2005/05/17 09:00 [entrez]
AID - S1566-0702(05)00033-0 [pii]
AID - 10.1016/j.autneu.2005.02.006 [doi]
PST - ppublish
SO  - Auton Neurosci. 2005 Apr 29;119(1):25-35. doi: 10.1016/j.autneu.2005.02.006. Epub 
      2005 Mar 23.