PMID- 15894338
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20171116
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 77
IP  - 13
DP  - 2005 Aug 12
TI  - alpha-Adrenergic and muscarinic cholinergic receptors are not involved in the 
      modulation of the parasympathetic baroreflex by the medial prefrontal cortex in 
      rats.
PG  - 1441-51
AB  - The medial prefrontal cortex (MPFC) is involved in cardiovascular control and 
      baroreflex modulation. Recent studies indicated that stimulation of MPFC 
      muscarinic receptors causes hypotensive responses whereas stimulation of alpha1- 
      but not of alpha2-adrenoceptors causes pressor responses in unanesthetized rats. 
      It has also been shown that the MPFC is involved in the modulation of the 
      parasympathetic component of the baroreflex in rats. We report that bilateral 
      injections of CoCl2 in the ventral portion of the MPFC (vMPFC) reduced the 
      parasympathetic component of the baroreflex, thus confirming the involvement of 
      local synapses. We further evaluated the effect of the pharmacologic block of 
      vMPFC alpha1- or alpha2-adrenoceptors and muscarinic receptors on the 
      vMPFC-related modulation of the parasympathetic component of the baroreflex in 
      unanesthetized rats. Bilateral microinjections of 10 nmol of the selective 
      alpha1-adrenoceptor antagonist WB4101 or 10 nmol of the selective 
      alpha2-adrenoceptors antagonist RX821002 into the MPFC did not affect the 
      baroreflex. Bilateral microinjections of 9 nmol of the muscarinic antagonist 
      atropine also did not affect baroreflex activity. The present results indicate 
      that although vMPFC alpha-adrenergic and muscarinic receptors are involved in 
      cardiovascular regulation, they do not mediate the vMPFC-related modulation of 
      the parasympathetic component of the baroreflex.
FAU - Resstel, L B M
AU  - Resstel LB
AD  - Department of Pharmacology, School of Medicine of Ribeirao Preto, University of 
      Sao Paulo, Ribeirao Preto, SP, 14090-090, Brazil.
FAU - Fernandes, K B P
AU  - Fernandes KB
FAU - Correa, F M A
AU  - Correa FM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Dioxanes)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 0 (Receptors, Muscarinic)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 3G0H8C9362 (Cobalt)
RN  - 7C0697DR9I (Atropine)
RN  - E27LB7P0ET (2-methoxyidazoxan)
RN  - E9H51OIT2B ((2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane)
RN  - EVS87XF13W (cobaltous chloride)
RN  - Y310PA316B (Idazoxan)
SB  - IM
MH  - Animals
MH  - Atropine/pharmacology
MH  - Baroreflex/*physiology
MH  - Cobalt/pharmacology
MH  - Dioxanes/pharmacology
MH  - Idazoxan/*analogs & derivatives/pharmacology
MH  - Male
MH  - Parasympathetic Nervous System/*physiology
MH  - Phenylephrine/pharmacology
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Adrenergic, alpha/*physiology
MH  - Receptors, Muscarinic/*physiology
EDAT- 2005/05/17 09:00
MHDA- 2005/08/19 09:00
CRDT- 2005/05/17 09:00
PHST- 2004/08/31 00:00 [received]
PHST- 2005/03/04 00:00 [accepted]
PHST- 2005/05/17 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/05/17 09:00 [entrez]
AID - S0024-3205(05)00369-3 [pii]
AID - 10.1016/j.lfs.2005.03.012 [doi]
PST - ppublish
SO  - Life Sci. 2005 Aug 12;77(13):1441-51. doi: 10.1016/j.lfs.2005.03.012.