PMID- 1589591
OWN - NLM
STAT- MEDLINE
DCOM- 19920624
LR  - 20190907
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 16
IP  - 3
DP  - 1992 May
TI  - Effect of IAP and chronic antidepressant administration on the 5HT1A receptor in 
      rat cortical membranes.
PG  - 339-49
AB  - 1. A possible coupling of the rat cerebral cortex 5-hydroxytryptamine (5HT)-1A 
      receptors to isletactivating protein (IAP, pertussis toxin) sensitive Gi protein 
      was investigated by studying the effects of a guanosine 5'-triphosphate (GTP) and 
      IAP injection to the rat ventricle. 2. Scatchard analysis showed that Bmax value 
      of the high-affinity componentin [3H]8-hydroxy-2-(di-n-propylamino) tetralin 
      (8-OH-DPAT) binding was decreased by pretreatment with IAP. 3. GTP caused a 
      significant decreased Bmax of the high affinity site for [3H]8-OH-DPAT binding. 
      It was noted that the IAP suppressed the cyclic AMP production by 5HT, VIP and 
      Forskolin. 4. These results suggest that the rat cortex 5HT-1A receptors are 
      linked to the Gi protein. 5. After 3 weeks chronic administration of 
      amitriptyline (5mg/kg), desipramine (5mg/kg), imipramine (5mg/kg), doxepin 
      (5mg/kg) and trazodone (10mg/kg), the receptor binding assay was carried out on 
      5HT-1A receptors. 6. It was observed that all the antidepressant drugs except for 
      imipramine increased the number of high-affinity sites of the 5HT-1A receptors in 
      the frontal cortex. 7. These results suggested that the increase of the Bmax for 
      the 5HT-1A receptor might be related to the effectiveness of the antidepressant 
      drugs.
FAU - Akiyoshi, J
AU  - Akiyoshi J
AD  - Department of Neuropsychiatry, Medical College of Oita, Japan.
FAU - Tsuchiyama, K
AU  - Tsuchiyama K
FAU - Yamada, K
AU  - Yamada K
FAU - Mizobe, Y
AU  - Mizobe Y
FAU - Nakamura, M
AU  - Nakamura M
FAU - Nagayama, H
AU  - Nagayama H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Antidepressive Agents)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Virulence Factors, Bordetella)
RN  - 20762-30-5 (Adenosine Diphosphate Ribose)
RN  - 250PJI13LM (Mianserin)
RN  - 333DO1RDJY (Serotonin)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 2.4.2.31 (Pertussis Toxin)
SB  - IM
MH  - Adenosine Diphosphate Ribose/metabolism
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Cerebral Cortex/cytology/drug effects/*metabolism
MH  - Guanosine Triphosphate/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mianserin/pharmacology
MH  - *Pertussis Toxin
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/drug effects/immunology/*metabolism
MH  - Serotonin/physiology
MH  - Virulence Factors, Bordetella/*pharmacology
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 10.1016/0278-5846(92)90085-s [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 1992 May;16(3):339-49. doi: 
      10.1016/0278-5846(92)90085-s.