PMID- 15896202
OWN - NLM
STAT- MEDLINE
DCOM- 20050923
LR  - 20081121
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 65
IP  - 6
DP  - 2005 Jun
TI  - Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis.
PG  - 544-8
AB  - Interleukin-18 (IL-18), a member of the IL-1 family, is known to play a relevant 
      role in rheumatoid arthritis (RA) physiopathology mainly by promoting the 
      inflammatory response. The aim of this work was to investigate the possible 
      implication of two single-nucleotide polymorphisms (SNPs) [-607 A/C (rs1946518) 
      and -137 G/C (rs187238)] within the IL-18-promoter region in RA predisposition 
      and clinical course. A total of 362 unrelated RA patients and 339 healthy 
      controls were genotyped using a real-time polymerase chain reaction (PCR) method 
      for the -607 A/C SNP and a sequence-specific PCR method (PCR-SSP) for the -137 
      G/C polymorphism. No statistically significant differences were observed for both 
      -607 and -137 IL-18-promoter polymorphisms between RA patients and controls, 
      considering either allelic or genotypic frequencies. In addition, no association 
      was found with the haplotypes inferred by the two polymorphisms and RA 
      susceptibility. This was also the case when RA patients were stratified according 
      to sex, age at the onset of the disease, rheumatoid factor status, and 
      extraarticular manifestations. Our data suggest that -607 A/C (rs1946518) and 
      -137 G/C (rs187238) polymorphisms within the IL-18-promoter region do not play a 
      major role in RA predisposition.
FAU - Rueda, B
AU  - Rueda B
AD  - Instituto de Parasitologia y Biomedicina, 18100 Armilla, Granada, Spain. 
      blarume@ipb.csic.es
FAU - Gonzalez-Gay, M A
AU  - Gonzalez-Gay MA
FAU - Mataran, L
AU  - Mataran L
FAU - Lopez-Nevot, M A
AU  - Lopez-Nevot MA
FAU - Martin, J
AU  - Martin J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Interleukin-18)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics
MH  - DNA/metabolism
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Inflammation
MH  - Interleukin-18/*genetics
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sex Factors
EDAT- 2005/05/18 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/05/18 09:00
PHST- 2005/05/18 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/05/18 09:00 [entrez]
AID - TAN408 [pii]
AID - 10.1111/j.1399-0039.2005.00408.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Jun;65(6):544-8. doi: 10.1111/j.1399-0039.2005.00408.x.