PMID- 15896220
OWN - NLM
STAT- MEDLINE
DCOM- 20050802
LR  - 20220311
IS  - 1323-1316 (Print)
IS  - 1323-1316 (Linking)
VI  - 59
IP  - 3
DP  - 2005 Jun
TI  - Behavioral and psychological symptoms of dementia characteristic of mild 
      Alzheimer patients.
PG  - 274-9
AB  - In order to clarify the characteristics of Behavioral and Psychological Symptoms 
      of Dementia (BPSD) in patients with mild Alzheimer's disease (AD), BPSD among the 
      severities of Clinical Dementia Rating (CDR) in 74 patients with AD were compared 
      using the Neuropsychiatric inventory (NPI). The result, when compared between 
      mild (CDR = 0.5, 1) and moderate or severe (CDR = 2, 3) AD, was a significant 
      difference in frequency of euphoria, disinhibition and aberrant motor behavior, 
      but no significant difference was found in frequency of delusions, 
      hallucinations, agitation, dysphoria, anxiety, apathy and irritability. In 
      addition, a significant difference was found in the mean scores of the composite 
      score for euphoria, apathy, disinhibition and aberrant motor behavior, but no 
      significant difference was found in the mean scores of the composite score for 
      delusions, hallucinations, agitation, dysphoria, anxiety and irritability. That 
      is, the mild AD groups (CDR 0.5 or 1) had delusions, hallucinations, agitation, 
      dysphoria, anxiety, apathy and irritability as frequently as the moderate or 
      severe AD groups (CDR 2 or 3), and had the equivalent level of composite scores 
      to the moderate or severe AD groups (CDR 2 or 3) in delusion, hallucination, 
      agitation, dysphoria, anxiety and irritability. Therefore, it was supposed that 
      psychotic symptoms (delusion, hallucination) and emotional symptoms (agitation, 
      dysphoria, anxiety, irritability) are important BPSD in patients with mild AD as 
      well as those with moderate or severe AD, and there are needs for health, welfare 
      and medical services for these symptoms.
FAU - Shimabukuro, Jin
AU  - Shimabukuro J
AD  - Department of Psychiatry, Tohoku University Hospital, Sendai, Japan. 
      cocoa-thk@umin.ac.jp
FAU - Awata, Shuichi
AU  - Awata S
FAU - Matsuoka, Hiroo
AU  - Matsuoka H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
SB  - IM
MH  - Affective Symptoms/psychology
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*psychology
MH  - *Behavior
MH  - Dementia/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/psychology
EDAT- 2005/05/18 09:00
MHDA- 2005/08/03 09:00
CRDT- 2005/05/18 09:00
PHST- 2005/05/18 09:00 [pubmed]
PHST- 2005/08/03 09:00 [medline]
PHST- 2005/05/18 09:00 [entrez]
AID - PCN1371 [pii]
AID - 10.1111/j.1440-1819.2005.01371.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2005 Jun;59(3):274-9. doi: 
      10.1111/j.1440-1819.2005.01371.x.