PMID- 15896492
OWN - NLM
STAT- MEDLINE
DCOM- 20050726
LR  - 20161124
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 381
IP  - 3
DP  - 2005 Jun 24
TI  - Inhibitory effect of gaseous neuromodulators in vasopressin and oxytocin release 
      induced by endotoxin in rats.
PG  - 320-4
AB  - Nitric oxide (NO) and carbon monoxide (CO) are endogenously synthesized gaseous 
      molecules that act as neurotransmitters in central nervous system. In this study 
      we investigated the modulatory role of NO and CO in lipopolysaccharide 
      (LPS)-induced vasopressin and oxytocin secretion. Intracerebroventricular 
      (i.c.v.) injection of N omega-L-nitro-arginine methyl ester (L-NAME), 
      3-morpholino-sydnonimine (SIN-1), zinc deuteroporphyrin 2,4-bis glicol (ZnDPBG) 
      or hemin did not change the basal vasopressin and oxytocin plasma levels. After 
      endovenous LPS administration, plasma vasopressin and oxytocin increased, 
      reaching a peak at 60 min, and returning to basal levels afterwards. LPS 
      administration induced a higher vasopressin and oxytocin plasma levels in rats 
      previously treated with L-NAME and ZnDPBG (P<0.05) compared to rats pre-treated 
      with vehicle. On the other hand, in rats previously treated with SIN-1 or hemin, 
      there was a significant reduction in the vasopressin and oxytocin secretion. 
      These findings confirm the inhibitory role of NO and CO in the LPS-induced 
      vasopressin and oxytocin secretion.
FAU - Giusti-Paiva, Alexandre
AU  - Giusti-Paiva A
AD  - Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade 
      de Sao Paulo, 14049-900 Ribeirao Preto, Sao Paulo, Brazil.
FAU - Elias, Lucila Leico Kagohara
AU  - Elias LL
FAU - Antunes-Rodrigues, Jose
AU  - Antunes-Rodrigues J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Neurotransmitter Agents)
RN  - 11000-17-2 (Vasopressins)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 50-56-6 (Oxytocin)
RN  - 7U1EE4V452 (Carbon Monoxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
SB  - IM
MH  - Animals
MH  - Carbon Monoxide/pharmacology
MH  - Enzyme Inhibitors/pharmacology
MH  - Heme Oxygenase (Decyclizing)/drug effects/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Male
MH  - Neurotransmitter Agents/*pharmacology
MH  - Nitric Oxide/pharmacology
MH  - Nitric Oxide Synthase/drug effects/metabolism
MH  - Oxytocin/biosynthesis/blood/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Vasopressins/biosynthesis/blood/*drug effects
EDAT- 2005/05/18 09:00
MHDA- 2005/07/27 09:00
CRDT- 2005/05/18 09:00
PHST- 2004/12/16 00:00 [received]
PHST- 2005/02/14 00:00 [revised]
PHST- 2005/02/16 00:00 [accepted]
PHST- 2005/05/18 09:00 [pubmed]
PHST- 2005/07/27 09:00 [medline]
PHST- 2005/05/18 09:00 [entrez]
AID - S0304-3940(05)00217-X [pii]
AID - 10.1016/j.neulet.2005.02.040 [doi]
PST - ppublish
SO  - Neurosci Lett. 2005 Jun 24;381(3):320-4. doi: 10.1016/j.neulet.2005.02.040.