PMID- 15896974
OWN - NLM
STAT- MEDLINE
DCOM- 20060317
LR  - 20061115
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 31
IP  - 1
DP  - 2005 Jul 7
TI  - Circulating beta-chemokines and matrix metalloproteinase-9/tissue inhibitor of 
      metalloproteinase-1 system in hemodialyzed patients--role of oxidative stress.
PG  - 18-24
AB  - Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), 
      beta-chemokines, increased oxidative stress (SOX) and inflammation have been 
      implicated as important factors in atherosclerosis and vascular remodeling. We 
      hypothesized the possible roles of beta-chemokines [monocyte chemoattractant 
      protein-1 (MCP-1), macrophage inflammatory proteins (MIP-1alpha, MIP-1beta) and 
      regulated upon activation, normal T-cell expressed and secreted (RANTES)] as 
      regulators of the metabolism of the vascular extracellular matrix in conditions 
      of increased SOX in hemodialysis (HD) patients. We compared pre-dialysis levels 
      of MMP-9/TIMP-1 system, beta-chemokines, Cu/Zn superoxide dismutase (Cu/Zn SOD) 
      as a marker of SOX and C-reactive protein (CRP) as a marker of inflammation in HD 
      patients with and without cardiovascular disease (CVD) to those of controls. HD 
      patients, particularly those with CVD, showed a significant increase in values of 
      Cu/Zn SOD, CRP, TIMP-1, TIMP-1/MMP-9 ratio, MCP-1 and MIP-1beta, whereas RANTES 
      levels were lower than in the controls. The levels of MIP-1alpha as well as MMP-9 
      in all HD groups were similar to the controls. The positive correlations were 
      observed between the MMP-9/TIMP-1 system and beta-chemokines, SOX and 
      inflammation in whole HD group and in the subgroup with CVD. Multivariate 
      analysis showed that the duration of dialysis followed by Cu/Zn SOD, MIP-1alpha 
      and beta levels were the significant positive predictors of TIMP-1. In 
      conclusion, our data show that MMP-9/TIMP-1 system and beta-chemokines could 
      cooperate in conditions of elevated SOX, which ultimately predisposes 
      hemodialysis patients to accelerated atherosclerosis.
FAU - Pawlak, Krystyna
AU  - Pawlak K
AD  - Department of Nephrology and Transplantology, Medical University of Bialystok, 14 
      Zurawia Street, 15-540 Bialystok, Poland. krystynapawlak@poczta.onet.pl
FAU - Pawlak, Dariusz
AU  - Pawlak D
FAU - Mysliwiec, Michal
AU  - Mysliwiec M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Chemokines, CC)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - C-Reactive Protein/metabolism
MH  - Cardiovascular Diseases/blood
MH  - Chemokines, CC/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 9/*blood/metabolism
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - *Renal Dialysis
MH  - Superoxide Dismutase/blood/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-1/*blood/metabolism
EDAT- 2005/05/18 09:00
MHDA- 2006/03/18 09:00
CRDT- 2005/05/18 09:00
PHST- 2004/05/12 00:00 [received]
PHST- 2004/10/05 00:00 [revised]
PHST- 2005/02/21 00:00 [accepted]
PHST- 2005/05/18 09:00 [pubmed]
PHST- 2006/03/18 09:00 [medline]
PHST- 2005/05/18 09:00 [entrez]
AID - S1043-4666(05)00109-2 [pii]
AID - 10.1016/j.cyto.2004.12.020 [doi]
PST - ppublish
SO  - Cytokine. 2005 Jul 7;31(1):18-24. doi: 10.1016/j.cyto.2004.12.020.