PMID- 15897479
OWN - NLM
STAT- MEDLINE
DCOM- 20051121
LR  - 20111117
IS  - 1071-7323 (Print)
IS  - 1071-7323 (Linking)
VI  - 13
IP  - 4
DP  - 2005 Apr
TI  - Insulin sensitivity determines the effectiveness of dietary macronutrient 
      composition on weight loss in obese women.
PG  - 703-9
AB  - OBJECTIVE: To determine whether macronutrient composition of a hypocaloric diet 
      can enhance its effectiveness and whether insulin sensitivity (Si) affects the 
      response to hypocaloric diets. RESEARCH METHODS AND PROCEDURES: Obese nondiabetic 
      insulin-sensitive (fasting insulin < 10 microU/mL; n = 12) and obese nondiabetic 
      insulin-resistant (fasting insulin > 15 microU/mL; n = 9) women (23 to 53 years 
      old) were randomized to either a high carbohydrate (CHO) (HC)/low fat (LF) (60% 
      CHO, 20% fat) or low CHO (LC)/high fat (HF) (40% CHO, 40% fat) hypocaloric diet. 
      Primary outcome measures after a 16-week dietary intervention were: changes in 
      body weight (BW), Si, resting metabolic rate, and fasting lipids. RESULTS: 
      Insulin-sensitive women on the HC/LF diet lost 13.5 +/- 1.2% (p < 0.001) of their 
      initial BW, whereas those on the LC/HF diet lost 6.8 +/- 1.2% (p < 0.001; p < 
      0.002 between the groups). In contrast, among the insulin-resistant women, those 
      on the LC/HF diet lost 13.4 +/- 1.3% (p < 0.001) of their initial BW as compared 
      with 8.5 +/- 1.4% (p < 0.001) lost by those on the HC/LF diet (p < 0.04 between 
      two groups). These differences could not be explained by changes in resting 
      metabolic rate, activity, or intake. Overall, changes in Si were associated with 
      the degree of weight loss (r = -0.57, p < 0.05). DISCUSSION: The state of Si 
      determines the effectiveness of macronutrient composition of hypocaloric diets in 
      obese women. For maximal benefit, the macronutrient composition of a hypocaloric 
      diet may need to be adjusted to correspond to the state of Si.
FAU - Cornier, Marc-Andre
AU  - Cornier MA
AD  - Department of Medicine, University of Colorado Health Sciences Center, Denver, 
      CO, USA.
FAU - Donahoo, W Troy
AU  - Donahoo WT
FAU - Pereira, Rocio
AU  - Pereira R
FAU - Gurevich, Inga
AU  - Gurevich I
FAU - Westergren, Rickard
AU  - Westergren R
FAU - Enerback, Sven
AU  - Enerback S
FAU - Eckel, Peter J
AU  - Eckel PJ
FAU - Goalstone, Marc L
AU  - Goalstone ML
FAU - Hill, James O
AU  - Hill JO
FAU - Eckel, Robert H
AU  - Eckel RH
FAU - Draznin, Boris
AU  - Draznin B
LA  - eng
GR  - DK48520/DK/NIDDK NIH HHS/United States
GR  - M01 RR00051/RR/NCRR NIH HHS/United States
GR  - RR16185/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Obes Res
JT  - Obesity research
JID - 9305691
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Basal Metabolism
MH  - Body Mass Index
MH  - *Diet, Reducing
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/administration & dosage
MH  - Energy Intake
MH  - Energy Metabolism
MH  - Fasting
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Middle Aged
MH  - Obesity/physiopathology/*therapy
MH  - Treatment Outcome
MH  - *Weight Loss
EDAT- 2005/05/18 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/05/18 09:00
PHST- 2005/05/18 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/05/18 09:00 [entrez]
AID - 13/4/703 [pii]
AID - 10.1038/oby.2005.79 [doi]
PST - ppublish
SO  - Obes Res. 2005 Apr;13(4):703-9. doi: 10.1038/oby.2005.79.