PMID- 15898010
OWN - NLM
STAT- MEDLINE
DCOM- 20050915
LR  - 20220410
IS  - 0210-0010 (Print)
IS  - 0210-0010 (Linking)
VI  - 40
IP  - 9
DP  - 2005 May 1-15
TI  - [Benign idiopathic external hydrocephalus (benign subdural collection) in 39 
      children: its natural history and relation to familial macrocephaly].
PG  - 513-7
AB  - INTRODUCTION: Benign idiopathic external hydrocephalus (BIEH) is an age-dependent 
      disorder that is self-limiting in time and has an uncertain aetiology. PATIENTS 
      AND METHODS: A retrospective study was conducted involving 39 patients (16 girls 
      and 23 boys) with BIEH. The following data were analysed for each patient: age, 
      sex, family history, history concerning pregnancy, childbirth and neonatal 
      period, postnatal history, data from clinical records and from physical 
      examinations, progress of psychomotor development, findings from the first and 
      successive neuroimaging studies, results of other complementary examinations, 
      clinical and neuroimaging situation at the last check-up that was carried out, 
      length of clinical control, age at which subdural effusion disappeared, and any 
      other relevant associated facts. RESULTS: Age at diagnosis ranged from 1.33 and 
      25 months (mean: 8.4 months); in 38.46% of cases there was a history of 
      macrocephalia in one of the progenitors; in four of them the presence of 
      congenital macrocephalia was noted; in five, there was motor retardation and one 
      of them displayed psychomotor retardation; in 15, there was an association with a 
      slight dilatation of the lateral ventricles; the mean time of clinical control 
      was 3.36 years; the process was seen to resolve in 14 cases; the minimum age for 
      the disappearance of the subdural effusion was 9 months and the maximum was 8 
      years; macrocephalia persisted until the clinical control ended in 22 of the 
      cases. We also noted the presence of two cases of mitochondrial 
      encephalomyopathy, one craniosynostosis of the sagittal suture, one microdeletion 
      22q11.2, one a-1 antitrypsin deficiency, and one case of idiopathic bilateral 
      congenital palpebral ptosis. CONCLUSIONS: The subdural effusion and/or 
      macrocephalia persist in a high percentage of these patients and sometimes there 
      is a close relationship between this condition and benign familial macrocephalia. 
      Despite its benignity, it can influence psychomotor or motor retardation and 
      behavioural disorders. On rare occasions it may be associated to mitochondrial 
      encephalomyopathy and to the microdeletion 22q11.2.
FAU - Castro-Gago, M
AU  - Castro-Gago M
AD  - Departamento de Pediatria, Hospital Clinico Universitario de Santiago de 
      Compostela, La Choupana s/n, E-15706 Santiago de Compostela, Spain. 
      pdcastro@usc.es
FAU - Perez-Gomez, C
AU  - Perez-Gomez C
FAU - Novo-Rodriguez, M I
AU  - Novo-Rodriguez MI
FAU - Blanco-Barca, O
AU  - Blanco-Barca O
FAU - Alonso-Martin, A
AU  - Alonso-Martin A
FAU - Eiris-Punal, J
AU  - Eiris-Punal J
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Hidrocefalia externa idiopatica benigna (efusion subdural benigna) en 39 ninos: 
      evolucion natural y relacion con la macrocefalia familiar.
PL  - Spain
TA  - Rev Neurol
JT  - Revista de neurologia
JID - 7706841
SB  - IM
MH  - Cephalometry
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Hydrocephalus/etiology/*pathology/physiopathology
MH  - Infant
MH  - Male
MH  - Pregnancy
MH  - Retrospective Studies
MH  - *Skull/anatomy & histology/pathology
MH  - Subdural Space/*pathology
EDAT- 2005/05/18 09:00
MHDA- 2005/09/16 09:00
CRDT- 2005/05/18 09:00
PHST- 2005/05/18 09:00 [pubmed]
PHST- 2005/09/16 09:00 [medline]
PHST- 2005/05/18 09:00 [entrez]
AID - rn2004534 [pii]
PST - ppublish
SO  - Rev Neurol. 2005 May 1-15;40(9):513-7.