PMID- 15898940
OWN - NLM
STAT- MEDLINE
DCOM- 20050725
LR  - 20220409
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 76
IP  - 5
DP  - 2005 May
TI  - Interleukin-18 concentrations and the pathogenesis of periodontal disease.
PG  - 785-90
AB  - BACKGROUND: Interleukin-18 (IL-18) is reported as an important regulatory 
      cytokine in non-oral inflammation. Our objective was to compare the 
      concentrations of IL-18 within diseased and healthy human gingiva with 
      concentrations of other T(H)1 and T(H)2 cytokines to determine possible effects 
      of IL-18 on gingival inflammation. METHODS: Gingival biopsies were obtained prior 
      to routine tooth extraction. Gingiva was grouped by the depth of the adjacent 
      gingival sulcus: < or =3 healthy (featuring no bleeding on probing) and > or =3 
      mm diseased (featuring bleeding on probing). Diseased gingiva was subdivided into 
      3, 4 to 6 and >6 mm groups. Gingival interleukin (IL)-2, IL-4, IL-6, IL-10, 
      IL-12, IL-18, and interferon (IFN)-gamma concentrations were assessed by enzyme 
      linked immunosorbent assay (ELISA). Data were compared by factorial analysis of 
      variance and the Pearson's correlation test. RESULTS: Concentrations of IL-2, 
      IL-4, IL-6, IL-10, IL-18, and IFN-gamma adjacent to 4 to 6 mm diseased sites were 
      greater than adjacent to < or =3 mm healthy sites (P <0.001). IL-12 
      concentrations were lower within diseased than within healthy gingiva (P <0.001). 
      IL-6 and IL-18 concentrations were greater adjacent to >6 mm sites compared to 
      healthy sites (P <0.001); the concentrations of the other cytokines (except 
      IL-12) were similar to healthy sites. IL-6 and IL-18 concentrations were 
      positively correlated, and IFN-gamma and IL-12 negatively correlated, with the 
      adjacent gingival sulcular depth. CONCLUSIONS: Periodontal inflammation may not 
      successfully resolve because of accumulation of IL-6 and IL-18, and decreased 
      concentrations of IL-12, within diseased gingiva. Because of the highly 
      significant correlation between IL-18 concentration and gingival sulcular depth, 
      IL-18 may be a useful target for either preventive or palliative therapy for 
      periodontitis.
FAU - Johnson, R B
AU  - Johnson RB
AD  - Department of Periodontics and Preventive Sciences, University of Mississipi 
      Medical Center, Jackson, MS 39216, USA. rjohnson@sod.unsmed.edu
FAU - Serio, F G
AU  - Serio FG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Biomarkers/analysis
MH  - Female
MH  - Gingiva/*immunology
MH  - Humans
MH  - Interferon-gamma/*analysis
MH  - Interleukin-18/*analysis
MH  - Interleukins/analysis
MH  - Male
MH  - Middle Aged
MH  - Periodontal Diseases/*immunology
MH  - Periodontal Pocket/immunology
EDAT- 2005/05/19 09:00
MHDA- 2005/07/26 09:00
CRDT- 2005/05/19 09:00
PHST- 2005/05/19 09:00 [pubmed]
PHST- 2005/07/26 09:00 [medline]
PHST- 2005/05/19 09:00 [entrez]
AID - 10.1902/jop.2005.76.5.785 [doi]
PST - ppublish
SO  - J Periodontol. 2005 May;76(5):785-90. doi: 10.1902/jop.2005.76.5.785.