PMID- 15899371
OWN - NLM
STAT- MEDLINE
DCOM- 20051011
LR  - 20131121
IS  - 1570-0232 (Print)
IS  - 1570-0232 (Linking)
VI  - 820
IP  - 2
DP  - 2005 Jun 25
TI  - Simultaneous determination of methylephedrine and noscapine in human plasma by 
      liquid chromatography-tandem mass spectrometry.
PG  - 175-82
AB  - A selective and sensitive method has been developed and validated for 
      simultaneous quantification of methylephedrine and noscapine in human plasma. 
      Analytes were extracted from human plasma samples by liquid-liquid extraction, 
      separated on a Diamonsil C18 column and detected by tandem mass spectrometer with 
      an atmospheric pressure chemical ionization (APCI) interface. Diphenhydramine was 
      used as the internal standard (I.S.). The method was found to be precise and 
      accurate within the linear range 0.1-100 ng/ml for each analyte. The intra- and 
      inter-day relative standard deviations (R.S.D.s) were below 5.2% for 
      methylephedrine and 6.7% for noscapine. The inter-day relative error (RE) as 
      determined from quality control samples (QCs) was less than 3.0% for each 
      analyte. The assay was successfully employed in a pharmacokinetic study after an 
      oral administration of a multicomponent formulation containing 20 mg 
      DL-methylephedrine hydrochloride, 16 mg noscapine, 300 mg paracetamol and 1mg of 
      chlorpheniramine maleate.
FAU - Zhu, Lin
AU  - Zhu L
AD  - Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical 
      University, 103 Wenhua Road, Shenyang 110016, PR China.
FAU - Chen, Xiaoyan
AU  - Chen X
FAU - Zhang, Yifan
AU  - Zhang Y
FAU - Yu, Hualing
AU  - Yu H
FAU - Zhong, Dafang
AU  - Zhong D
LA  - eng
PT  - Journal Article
DEP - 20050422
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 60VH42A1KJ (N-methylephedrine)
RN  - 8V32U4AOQU (Noscapine)
RN  - GN83C131XS (Ephedrine)
SB  - IM
MH  - Atmospheric Pressure
MH  - Calibration
MH  - Chromatography, Liquid/*methods
MH  - Ephedrine/*analogs & derivatives/blood
MH  - Humans
MH  - Mass Spectrometry/*methods
MH  - Noscapine/*blood
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2005/05/19 09:00
MHDA- 2005/10/12 09:00
CRDT- 2005/05/19 09:00
PHST- 2005/01/14 00:00 [received]
PHST- 2005/03/03 00:00 [revised]
PHST- 2005/03/03 00:00 [accepted]
PHST- 2005/05/19 09:00 [pubmed]
PHST- 2005/10/12 09:00 [medline]
PHST- 2005/05/19 09:00 [entrez]
AID - S1570-0232(05)00205-9 [pii]
AID - 10.1016/j.jchromb.2005.03.010 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jun 25;820(2):175-82. doi: 
      10.1016/j.jchromb.2005.03.010. Epub 2005 Apr 22.