PMID- 15899380
OWN - NLM
STAT- MEDLINE
DCOM- 20050705
LR  - 20061115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 159
IP  - 2
DP  - 2005 Jun
TI  - Analysis of ameloblastomas by comparative genomic hybridization and fluorescence 
      in situ hybridization.
PG  - 99-104
AB  - In order to characterize the chromosomal alterations in ameloblastomas, a 
      combination of comparative genomic hybridization (CGH) and fluorescence in situ 
      hybridization (FISH) techniques was performed on 9 tumors. Chromosomal 
      alterations including a gain at 1q and losses at 1pter, 10q, and 22q could be 
      detected by CGH only in 1 tumor. Interphase FISH analysis, using centromeric 
      probes for chromosomes 1, 10, and 22 as well as region-specific probes for 1p36 
      and 10q26, revealed the most frequent alterations to exist in the tumor with the 
      abnormal CGH profile. These alterations included marked to slight increases of 
      monosomic cells for chromosome 10 (91.5%), 10q26 (35.8%), 1p36 (24.4%), and 
      chromosome 22 (18.8%), as well as significant elevations of trisomic cells for 
      chromosome 1 (41.2%). Moreover, FISH analysis revealed a frequent loss of 
      chromosome 22 in all tumors examined, except for one lesion, indicating that loss 
      of the entire or a part of this chromosome is a common event in ameloblastomas, 
      possibly being a predisposing factor to ameloblastoma tumorigenesis.
FAU - Toida, Makoto
AU  - Toida M
AD  - Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of 
      Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. toida@cc.gifu-u.ac.jp
FAU - Balazs, Margit
AU  - Balazs M
FAU - Treszl, Andrea
AU  - Treszl A
FAU - Rakosy, Zsuzsa
AU  - Rakosy Z
FAU - Kato, Keizo
AU  - Kato K
FAU - Yamazaki, Yutaka
AU  - Yamazaki Y
FAU - Matsui, Toshiaki
AU  - Matsui T
FAU - Suwa, Tatsuhiko
AU  - Suwa T
FAU - Hatakeyama, Daijiro
AU  - Hatakeyama D
FAU - Makita, Hiroki
AU  - Makita H
FAU - Mori, Sojiro
AU  - Mori S
FAU - Yamashita, Tomomi
AU  - Yamashita T
FAU - Shibata, Toshiyuki
AU  - Shibata T
FAU - Adany, Roza
AU  - Adany R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Ameloblastoma
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 10
MH  - Chromosomes, Human, Pair 22
MH  - Female
MH  - Gene Dosage
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
EDAT- 2005/05/19 09:00
MHDA- 2005/07/06 09:00
CRDT- 2005/05/19 09:00
PHST- 2004/07/06 00:00 [received]
PHST- 2004/09/23 00:00 [revised]
PHST- 2004/10/01 00:00 [accepted]
PHST- 2005/05/19 09:00 [pubmed]
PHST- 2005/07/06 09:00 [medline]
PHST- 2005/05/19 09:00 [entrez]
AID - S0165-4608(04)00480-7 [pii]
AID - 10.1016/j.cancergencyto.2004.10.004 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Jun;159(2):99-104. doi: 
      10.1016/j.cancergencyto.2004.10.004.