PMID- 15899384
OWN - NLM
STAT- MEDLINE
DCOM- 20050705
LR  - 20161124
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 159
IP  - 2
DP  - 2005 Jun
TI  - Acute promyelocytic leukemia with PML-RARA fusion on i(17q) and therapy-related 
      acute myeloid leukemia.
PG  - 129-36
AB  - We describe a patient with acute promyelocytic leukemia (APL) and the karyotype 
      46,XX,i(17)(q10) with PML-RARA fusion gene detected by fluorescence in situ 
      hybridization (FISH) and nested reverse transcriptase-polymerase chain reaction 
      (RT-PCR). FISH using dual-color translocation probes for PML (promyelocytic 
      leukemia) and RARA (retinoic acid receptor-alpha) showed fusion signal for 
      PML-RARA on both arms of i(17q). The patient attained complete remission (CR) 
      with all-trans retinoic acid treatment and became PML-RARA negative. One year 
      later, while PML-RARA negative on FISH and RT-PCR, the patient presented with 
      thrombocytopenia. Bone marrow examination suggested an acute monoblastic leukemia 
      (AML-M5a) including the karyotype 46,XX,t(8;16) (p11.2;p13.3),inv(11)(p15q22 
      approximately q23)[11]/47,idem,+i(8)(q10)[9]. She is currently in CR. The 
      occurrence of therapy related acute leukemia after successful therapy for APL is 
      an emerging problem.
FAU - Lee, Geok Yee
AU  - Lee GY
AD  - Cytogenetics Laboratory, Department of Pathology, Singapore General Hospital, 
      Block 6, Level 5, Room A4, Outram Road, 169608 Singapore. geokyee@hotmail.com
FAU - Christina, Sivaswaren
AU  - Christina S
FAU - Tien, Sim Leng
AU  - Tien SL
FAU - Ghafar, Anisah Bte Abdul
AU  - Ghafar AB
FAU - Hwang, William
AU  - Hwang W
FAU - Lim, Lay Cheng
AU  - Lim LC
FAU - Lim, Tse Hui
AU  - Lim TH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Promyelocytic Leukemia Protein)
RN  - 0 (RARA protein, human)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein)
RN  - 143220-95-5 (PML protein, human)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Antineoplastic Agents/*adverse effects
MH  - *Chromosomes, Human, Pair 17
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Isochromosomes
MH  - Karyotyping
MH  - Leukemia, Monocytic, Acute/*chemically induced
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - Middle Aged
MH  - Neoplasm Proteins/*genetics
MH  - Nuclear Proteins/genetics
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Promyelocytic Leukemia Protein
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinoic Acid Receptor alpha
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription Factors/genetics
MH  - Translocation, Genetic
MH  - Tretinoin/*adverse effects
MH  - Tumor Suppressor Proteins
EDAT- 2005/05/19 09:00
MHDA- 2005/07/06 09:00
CRDT- 2005/05/19 09:00
PHST- 2004/08/02 00:00 [received]
PHST- 2004/09/27 00:00 [revised]
PHST- 2004/09/29 00:00 [accepted]
PHST- 2005/05/19 09:00 [pubmed]
PHST- 2005/07/06 09:00 [medline]
PHST- 2005/05/19 09:00 [entrez]
AID - S0165-4608(04)00473-X [pii]
AID - 10.1016/j.cancergencyto.2004.09.019 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Jun;159(2):129-36. doi: 
      10.1016/j.cancergencyto.2004.09.019.