PMID- 15899392
OWN - NLM
STAT- MEDLINE
DCOM- 20050705
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 159
IP  - 2
DP  - 2005 Jun
TI  - Two cases of acute myeloid leukemia with t(11;17) associated with varying 
      morphology and immunophenotype: rearrangement of the MLL gene and a region 
      proximal to the RARalpha gene.
PG  - 168-73
AB  - This report describes 2 cases of acute myeloid leukemia (AML), which based on the 
      WHO classification would be classified as AML with an 11q23 (MLL) abnormality, 
      but with contrasting morphologic and immunophenotypic profiles. One case had 
      monocytic features (morphologically and immunophenotypically) with a 
      t(11;17)(q23;q21), a previously identified variant translocation in acute 
      promyelocytic leukemia (APL). The second case had morphologic and 
      immunophenotypic features of APL associated with a t(11;17)(q23;q25). In both 
      cases, fluorescence-in-situ hybridization (FISH) analysis demonstrated that the 
      11q23 breakpoint involved the MLL gene, but RARalpha was not involved in the 17q 
      breakpoints. These cases illustrate the importance of FISH analysis to confirm 
      the presence of a particular recurring rearrangement.
FAU - Kang, Loveleen C
AU  - Kang LC
AD  - Division of Hematopathology, Department of Pathology and Laboratory Medicine, 
      Campus Box 7525, University of North Carolina, Chapel Hill, NC 27599-7525, USA.
FAU - Smith, Scott V
AU  - Smith SV
FAU - Kaiser-Rogers, Kathleen
AU  - Kaiser-Rogers K
FAU - Rao, Kathleen
AU  - Rao K
FAU - Dunphy, Cherie H
AU  - Dunphy CH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (RARA protein, human)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Acute Disease
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 17
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Gene Rearrangement
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - Proto-Oncogenes/*genetics
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinoic Acid Receptor alpha
MH  - Transcription Factors/*genetics
MH  - *Translocation, Genetic
EDAT- 2005/05/19 09:00
MHDA- 2005/07/06 09:00
CRDT- 2005/05/19 09:00
PHST- 2004/08/06 00:00 [received]
PHST- 2004/10/14 00:00 [revised]
PHST- 2004/10/15 00:00 [accepted]
PHST- 2005/05/19 09:00 [pubmed]
PHST- 2005/07/06 09:00 [medline]
PHST- 2005/05/19 09:00 [entrez]
AID - S0165-4608(04)00506-0 [pii]
AID - 10.1016/j.cancergencyto.2004.10.009 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Jun;159(2):168-73. doi: 
      10.1016/j.cancergencyto.2004.10.009.