PMID- 15899393
OWN - NLM
STAT- MEDLINE
DCOM- 20050705
LR  - 20050518
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 159
IP  - 2
DP  - 2005 Jun
TI  - Unique three-way translocation, t(3;14;18)(q27;q32;q21), in follicular lymphoma.
PG  - 174-6
AB  - A 43-year-old woman was diagnosed as having stage IV follicular lymphoma. 
      Phenotypically, the lymphoma cells were CD5(-), CD10(+), CD19(+), CD20(+), 
      CD23(-), HLA-DR(+), and IgM-lambda(+). Conventional chromosomal analysis showed a 
      three-way t(3;14;18)(q27;q32;q21) in the lymphoma cells, which was confirmed by 
      spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH). 
      Immunohistochemistry revealed that both BCL2 and BCL6 proteins were expressed in 
      the lymphoma cells, whereas only the BCL6 gene, and not the BCL2 gene, was 
      rearranged by Southern blotting. The patient received combination chemotherapy 
      and has been well for 3 years. This is the first reported case showing a 
      three-way translocation involving 2 major lymphoma-specific abnormalities, 3q27 
      and t(14;18)(q32;q21).
FAU - Okano, Akira
AU  - Okano A
AD  - Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural 
      University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. 
      aokano@koto.kpu-m.ac.jp
FAU - Nakano, Sonoko
AU  - Nakano S
FAU - Namura, Kyoko
AU  - Namura K
FAU - Yamada, Noriko
AU  - Yamada N
FAU - Uchida, Ryo
AU  - Uchida R
FAU - Fuchida, Shin-Ichi
AU  - Fuchida S
FAU - Okamoto, Masashi
AU  - Okamoto M
FAU - Ochiai, Naoya
AU  - Ochiai N
FAU - Shimazaki, Chihiro
AU  - Shimazaki C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Blotting, Southern
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 18
MH  - *Chromosomes, Human, Pair 3
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphoma, Follicular/*genetics
MH  - *Translocation, Genetic
EDAT- 2005/05/19 09:00
MHDA- 2005/07/06 09:00
CRDT- 2005/05/19 09:00
PHST- 2004/09/07 00:00 [received]
PHST- 2004/10/07 00:00 [revised]
PHST- 2004/10/25 00:00 [accepted]
PHST- 2005/05/19 09:00 [pubmed]
PHST- 2005/07/06 09:00 [medline]
PHST- 2005/05/19 09:00 [entrez]
AID - S0165-4608(04)00531-X [pii]
AID - 10.1016/j.cancergencyto.2004.10.014 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Jun;159(2):174-6. doi: 
      10.1016/j.cancergencyto.2004.10.014.