PMID- 15899478
OWN - NLM
STAT- MEDLINE
DCOM- 20050829
LR  - 20131121
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 516
IP  - 1
DP  - 2005 May 23
TI  - 3,4-Methylenedioxymethamphetamine and naloxone in rat rotational behaviour and 
      open field.
PG  - 34-9
AB  - It has recently been shown that 3,4-Methylenedioxymethamphetamine (MDMA) has an 
      anti-parkinsonian effect in rodent models of Parkinson's disease. The mechanism 
      of this anti-parkinsonian action is unknown. Opioids have been suggested to play 
      a role in MDMA-induced behaviour. We therefore investigated MDMA and naloxone in 
      the rat rotational behavioural model. Male Sprague-Dawley rats were lesioned 
      unilaterally with 6-hydroxydopamine at the medial forebrain bundle. 
      Administration of R/S-MDMA (5 mg/kg, s.c.) produced ipsilateral rotations. 
      Naloxone (2, 5, 10 mg/kg, s.c.) did not produce rotations on its own but reduced 
      the number of MDMA-induced ipsilateral rotations. This effect was not 
      dose-dependent. In contrast to reports on mice, in unlesioned animals, naloxone 
      (10 mg/kg, s.c.) did not block MDMA (5 mg/kg, s.c.)-induced hyperactivity in an 
      open field in our experiment. It is concluded that endogenous opioids play a role 
      in MDMA's action in the rat rotational behavioural model.
FAU - Lebsanft, Heike B
AU  - Lebsanft HB
AD  - Department Neuropharmacology, Zoological Institute, Faculty of Biology, 
      University of Tuebingen, Auf der Morgenstelle 28 E, 72076 Tuebingen, Germany. 
      heike.lebsanft@uni-tuebingen.de
FAU - Kovar, Karl-Artur
AU  - Kovar KA
FAU - Schmidt, Werner J
AU  - Schmidt WJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Hallucinogens)
RN  - 0 (Narcotic Antagonists)
RN  - 36B82AMQ7N (Naloxone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Naloxone/*pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2005/05/19 09:00
MHDA- 2005/08/30 09:00
CRDT- 2005/05/19 09:00
PHST- 2005/02/14 00:00 [received]
PHST- 2005/04/13 00:00 [revised]
PHST- 2005/04/14 00:00 [accepted]
PHST- 2005/05/19 09:00 [pubmed]
PHST- 2005/08/30 09:00 [medline]
PHST- 2005/05/19 09:00 [entrez]
AID - S0014-2999(05)00434-6 [pii]
AID - 10.1016/j.ejphar.2005.04.020 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2005 May 23;516(1):34-9. doi: 10.1016/j.ejphar.2005.04.020.