PMID- 15900551
OWN - NLM
STAT- MEDLINE
DCOM- 20051110
LR  - 20101118
IS  - 1522-1946 (Print)
IS  - 1522-1946 (Linking)
VI  - 65
IP  - 2
DP  - 2005 Jun
TI  - Low-molecular-weight heparin vs. unfractionated heparin in percutaneous coronary 
      intervention: a combined analysis.
PG  - 212-21
AB  - This meta-analysis assessed the rates of the efficacy and safety endpoints with 
      intravenous low-molecular-weight heparin (LMWH) compared with unfractionated 
      heparin (UFH) in patients undergoing percutaneous coronary intervention (PCI). 
      Subcutaneous LMWH has compared favorably with UFH, but limited experience exists 
      with intravenous LMWH for immediate anticoagulation in PCI. The meta-analysis 
      included data from eight randomized trials in which patients received LMWH (n = 
      1,037) or UFH (n = 978) during PCI. Seven additional nonrandomized 
      studies/registries were analyzed to assess the efficacy and safety of LMWH during 
      PCI. Efficacy endpoints were ischemic events (usually a composite of death, 
      myocardial infarction, and urgent revascularization) and the safety endpoint was 
      bleeding (major, minor, or all bleeding). In the randomized studies, LMWH was 
      comparable with UFH in terms of efficacy (6.2% vs. 7.5%) and major bleeding (0.9% 
      vs. 1.8%). The analysis of pooled data, randomized or not, suggests potential 
      improved efficacy (5.8% vs. 7.6%) and reduced major bleeding (0.6% vs. 1.8%) with 
      LMWH (n = 3,787) compared with UFH (n = 978). During PCI, intravenous LMWH 
      without coagulation monitoring has the potential to be at least as safe and 
      efficacious as intravenous UFH. Further studies of LMWHs in PCI are therefore 
      required.
CI  - Copyright 2005 Wiley-Liss, Inc
FAU - Borentain, Maria
AU  - Borentain M
AD  - Institut de Cardiologie, Pitie-Salpetriere University Hospital, Paris, France.
FAU - Montalescot, Gilles
AU  - Montalescot G
FAU - Bouzamondo, Anissa
AU  - Bouzamondo A
FAU - Choussat, Remi
AU  - Choussat R
FAU - Hulot, Jean-Sebastien
AU  - Hulot JS
FAU - Lechat, Philippe
AU  - Lechat P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - *Angioplasty, Balloon, Coronary/adverse effects
MH  - Coronary Disease/*therapy
MH  - Fibrinolytic Agents/*administration & dosage/adverse effects
MH  - Heparin/*administration & dosage/adverse effects
MH  - Heparin, Low-Molecular-Weight/*administration & dosage/adverse effects
MH  - Humans
MH  - Infusions, Intravenous
MH  - Postoperative Hemorrhage/etiology
MH  - Treatment Outcome
RF  - 51
EDAT- 2005/05/19 09:00
MHDA- 2005/11/11 09:00
CRDT- 2005/05/19 09:00
PHST- 2005/05/19 09:00 [pubmed]
PHST- 2005/11/11 09:00 [medline]
PHST- 2005/05/19 09:00 [entrez]
AID - 10.1002/ccd.20352 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2005 Jun;65(2):212-21. doi: 10.1002/ccd.20352.