PMID- 15901783
OWN - NLM
STAT- MEDLINE
DCOM- 20060323
LR  - 20181113
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 25
IP  - 20
DP  - 2005 May 18
TI  - Tuft calcium spikes in accessory olfactory bulb mitral cells.
PG  - 5024-8
AB  - The mammalian accessory olfactory system is critical for the detection and 
      identification of pheromones and the representation of complex stimuli including 
      sex, genetic relatedness, and individual identity. Mitral cells, the principal 
      cells of the accessory olfactory bulb (AOB), receive monosynaptic input from the 
      sensory periphery and already show highly specific response properties, firing 
      selectively for combinations of genetic markers and gender-specific cues. 
      Vomeronasal sensory neuron axons form synapses onto distal tuft-like branches of 
      mitral cell primary dendrites. We have studied dendritic excitability and 
      synaptic integration in AOB mitral cell dendrites, and we show that dendrites of 
      accessory olfactory bulb mitral cells support action potential propagation and 
      can fire regenerative spike-like events that are likely to contribute to the 
      integration of inputs to these cells. These tuft spikes may be important for the 
      specificity of AOB mitral cell responses.
FAU - Urban, Nathaniel N
AU  - Urban NN
AD  - Department of Biological Sciences and Center for the Neural Basis of Cognition, 
      Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA. nurban@cmu.edu
FAU - Castro, Jason B
AU  - Castro JB
LA  - eng
GR  - R01 DC005798/DC/NIDCD NIH HHS/United States
GR  - R21 DC006631/DC/NIDCD NIH HHS/United States
GR  - R01 DC005798-01/DC/NIDCD NIH HHS/United States
GR  - R21 DC006631-01/DC/NIDCD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Axons/physiology
MH  - Calcium/*metabolism
MH  - Dendrites/physiology
MH  - Electric Stimulation/methods
MH  - Image Processing, Computer-Assisted/methods
MH  - In Vitro Techniques
MH  - Mice
MH  - Neurons/cytology/*physiology
MH  - Olfactory Bulb/*cytology
MH  - Patch-Clamp Techniques/methods
MH  - Presynaptic Terminals/physiology
PMC - PMC1262639
MID - NIHMS2425
EDAT- 2005/05/20 09:00
MHDA- 2006/03/24 09:00
PMCR- 2005/11/18
CRDT- 2005/05/20 09:00
PHST- 2005/05/20 09:00 [pubmed]
PHST- 2006/03/24 09:00 [medline]
PHST- 2005/05/20 09:00 [entrez]
PHST- 2005/11/18 00:00 [pmc-release]
AID - 25/20/5024 [pii]
AID - 10.1523/JNEUROSCI.0297-05.2005 [doi]
PST - ppublish
SO  - J Neurosci. 2005 May 18;25(20):5024-8. doi: 10.1523/JNEUROSCI.0297-05.2005.