PMID- 15901786
OWN - NLM
STAT- MEDLINE
DCOM- 20060323
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 25
IP  - 20
DP  - 2005 May 18
TI  - Physiological maturation of photoreceptors depends on the voltage-gated sodium 
      channel NaV1.6 (Scn8a).
PG  - 5046-50
AB  - Voltage-gated sodium channels (VGSCs) ensure the saltatory propagation of action 
      potentials along axons by acting as signal amplifiers at the nodes of Ranvier. In 
      the retina, activity mediated by VGSCs is important for the refinement of the 
      retinotectal map. Here, we conducted a full-field electroretinogram (ERG) study 
      on mice null for the sodium channel NaV1.6. Interestingly, the light-activated 
      hyperpolarization of photoreceptor cells (the a-wave) and the major "downstream" 
      components of the ERG, the b-wave and the oscillatory potentials, are markedly 
      reduced and delayed in these mice. The functional deficit was not associated with 
      any morphological abnormality. We demonstrate that Scn8a is expressed in the 
      ganglion and inner nuclear layers and at low levels in the outer nuclear layer 
      beginning shortly before the observed ERG deficit. Together, our data reveal a 
      previously unappreciated role for VGSCs in the physiological maturation of 
      photoreceptors.
FAU - Cote, Patrice D
AU  - Cote PD
AD  - Molecular Medicine Program, Ottawa Health Research Institute, and University of 
      Ottawa Center for Neuromuscular Disease, Ottawa, Ontario, K1H 8L6, Canada.
FAU - De Repentigny, Yves
AU  - De Repentigny Y
FAU - Coupland, Stuart G
AU  - Coupland SG
FAU - Schwab, Yannick
AU  - Schwab Y
FAU - Roux, Michel J
AU  - Roux MJ
FAU - Levinson, S Rock
AU  - Levinson SR
FAU - Kothary, Rashmi
AU  - Kothary R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (NAV1.6 Voltage-Gated Sodium Channel)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Scn8a protein, mouse)
RN  - 0 (Sodium Channels)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Dose-Response Relationship, Radiation
MH  - Electroretinography/methods
MH  - Gene Expression Regulation, Developmental/genetics/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Microscopy, Electron, Transmission/methods
MH  - NAV1.6 Voltage-Gated Sodium Channel
MH  - Nerve Tissue Proteins/deficiency/*physiology
MH  - Photic Stimulation/methods
MH  - Photoreceptor Cells/growth & development/*physiology/radiation 
      effects/ultrastructure
MH  - Sodium Channels/deficiency/*physiology
PMC - PMC6724868
EDAT- 2005/05/20 09:00
MHDA- 2006/03/24 09:00
PMCR- 2005/11/18
CRDT- 2005/05/20 09:00
PHST- 2005/05/20 09:00 [pubmed]
PHST- 2006/03/24 09:00 [medline]
PHST- 2005/05/20 09:00 [entrez]
PHST- 2005/11/18 00:00 [pmc-release]
AID - 25/20/5046 [pii]
AID - 10.1523/JNEUROSCI.4692-04.2005 [doi]
PST - ppublish
SO  - J Neurosci. 2005 May 18;25(20):5046-50. doi: 10.1523/JNEUROSCI.4692-04.2005.