PMID- 15902366
OWN - NLM
STAT- MEDLINE
DCOM- 20090326
LR  - 20050519
IS  - 1615-6692 (Electronic)
IS  - 0340-9937 (Linking)
VI  - 30
IP  - 3
DP  - 2005 May
TI  - [The coagulation cascade--clinical implications].
PG  - 170-5
AB  - The coagulation system is a cascade of complex, interacting steps, that can 
      selectively be inhibited in distinct ways. Thus, various therapeutic options are 
      offered, concerning primary hemostasis, which results in formation of a 
      platelet-rich thrombus, as well as secondary hemostasis, resulting in fibrin 
      formation. For patients with coronary artery disease, who have to undergo 
      percutaneous coronary intervention (PCI), a sufficient anticoagulant strategy is 
      essential for prevention of ischemic events, due to the activated state of the 
      coagulation system of these patients. Next to antiplatelet therapy, 
      unfractionated heparin (UFH) is a well-established concomitant intravenous 
      therapy during PCI. Also low-molecular-weight heparins (LMWH) are increasingly 
      used in this setting due to their favorable pharmacodynamic properties. The exact 
      value of these substances in comparison to UFH is not completely evaluated yet.
FAU - Langer, Harald
AU  - Langer H
AD  - Medizinische Klinik und Poliklinik, Abteilung III, Universitatsklinikum Tubingen, 
      Eberhard-Karls-Universitat Tubingen, Tubingen.
FAU - Gawaz, Meinrad
AU  - Gawaz M
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Die Gerinnungskaskade-Mechanismen und klinische Implikationen.
PL  - Germany
TA  - Herz
JT  - Herz
JID - 7801231
RN  - 0 (Anticoagulants)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 9001-31-4 (Fibrin)
SB  - IM
MH  - Anticoagulants/*administration & dosage
MH  - Blood Coagulation/*drug effects
MH  - Fibrin/*metabolism
MH  - Humans
MH  - Platelet Aggregation Inhibitors/*administration & dosage
MH  - Thrombosis/*physiopathology/*prevention & control
RF  - 40
EDAT- 2005/05/20 09:00
MHDA- 2009/03/27 09:00
CRDT- 2005/05/20 09:00
PHST- 2005/05/20 09:00 [pubmed]
PHST- 2009/03/27 09:00 [medline]
PHST- 2005/05/20 09:00 [entrez]
AID - 10.1007/s00059-005-2691-8 [doi]
PST - ppublish
SO  - Herz. 2005 May;30(3):170-5. doi: 10.1007/s00059-005-2691-8.