PMID- 15902698
OWN - NLM
STAT- MEDLINE
DCOM- 20051006
LR  - 20161124
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 76
IP  - 3
DP  - 2005 Jul
TI  - HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency 
      virus-related Kaposi's sarcoma.
PG  - 302-10
AB  - Polymorphisms of genes in the human leukocyte antigen (HLA) complex, particularly 
      those encoding HLA-DR, have been suggested as markers of susceptibility to 
      Kaposi's sarcoma (KS). We conducted a case-control study comparing 147 homosexual 
      men who developed KS after infection by human immunodeficiency virus-1 (HIV-1) 
      and human herpes virus 8 (HHV8) with 147 matched dually infected men without 
      HIV-associated KS (HIV-KS) from the Multicenter AIDS Cohort Study. HLA-B, DRB1, 
      DRB3, DRB4, DRB5, and DQB1 polymorphisms were examined by high-resolution 
      DNA-based methods. Differences in distributions of genetic variants were tested 
      by conditional logistic regression. Previously reported relationships with 
      HLA-DRB1 alleles could not be confirmed. Instead, other associations were 
      observed. In univariate analysis, KS was weakly associated with B*2702/5 (odds 
      ratio (OR)=0.40, 95% confidence interval (CI)=0.18-0.91). Similar or stronger 
      associations, positive or negative, were seen for haplotypes containing class II 
      alleles: DRB1*1302-DQB1*0604 (OR=3.67, 95% CI=1.02-13.1), DRB4 (DR53) haplotype 
      family members [OR=0.52, 95% CI=0.32-0.85], and DRB3 (DR52) haplotype family 
      members (OR=1.69, 95% CI=1.07-2.67). The B*1402-DRB1*0102 haplotype, which 
      invariably contains the V281L mutation in the 21-hydroxylase gene governing 
      adrenal steroid biosynthesis, occurred in five cases and one control (OR=5.0, 95% 
      CI=0.58-42.8). In a final multivariable analysis, only DRB1*1302-DQB1*0604 
      (OR=6.43, 95% CI=1.28-32.3, P=0.02) remained significantly associated with KS. 
      Associations of HLA-DRB families with HIV-KS could reflect underlying immune 
      dysregulation. The HLA B*1402-DRB1*0102 haplotype associated with increased risk 
      of KS might represent an antigen-presenting pathway unfavorable for immune 
      response to HHV8. Alternatively, the relationship might hold a clue to the 
      predilection of KS for men because that haplotype harbors the mutant form of the 
      21-hydroxylase gene.
CI  - Copyright (c) 2005 Wiley-Liss, Inc.
FAU - Dorak, M Tevfik
AU  - Dorak MT
AD  - Department of Epidemiology and Medicine, University of Alabama at Birmingham, 
      Birmingham, Alabama 35294-0022, USA.
FAU - Yee, Leland J
AU  - Yee LJ
FAU - Tang, Jianming
AU  - Tang J
FAU - Shao, Wenshuo
AU  - Shao W
FAU - Lobashevsky, Elena S
AU  - Lobashevsky ES
FAU - Jacobson, Lisa P
AU  - Jacobson LP
FAU - Kaslow, Richard A
AU  - Kaslow RA
LA  - eng
GR  - 5-MO1-RR-00722/RR/NCRR NIH HHS/United States
GR  - UO1-AI-35039/AI/NIAID NIH HHS/United States
GR  - UO1-AI-35040/AI/NIAID NIH HHS/United States
GR  - UO1-AI-35041/AI/NIAID NIH HHS/United States
GR  - UO1-AI-35042/AI/NIAID NIH HHS/United States
GR  - UO1-AI-35043/AI/NIAID NIH HHS/United States
GR  - UO1-AI-37613/AI/NIAID NIH HHS/United States
GR  - UO1-AI-37984/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQbeta antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - EC 1.14.14.16 (Steroid 21-Hydroxylase)
SB  - IM
MH  - Case-Control Studies
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HIV Infections/*complications
MH  - HLA-B Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Herpesvirus 8, Human/isolation & purification
MH  - Homosexuality, Male
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Sarcoma, Kaposi/etiology/*genetics
MH  - Steroid 21-Hydroxylase/genetics
EDAT- 2005/05/20 09:00
MHDA- 2005/10/07 09:00
CRDT- 2005/05/20 09:00
PHST- 2005/05/20 09:00 [pubmed]
PHST- 2005/10/07 09:00 [medline]
PHST- 2005/05/20 09:00 [entrez]
AID - 10.1002/jmv.20361 [doi]
PST - ppublish
SO  - J Med Virol. 2005 Jul;76(3):302-10. doi: 10.1002/jmv.20361.