PMID- 15902922
OWN - NLM
STAT- MEDLINE
DCOM- 20050711
LR  - 20190917
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 34
IP  - 2-3
DP  - 2004 Oct-Nov
TI  - Relation of tumor necrosis factor (TNF) gene polymorphisms with serum 
      concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy 
      drinkers.
PG  - 273-7
AB  - Tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) play a role in 
      the pathogenesis of alcoholic hepatitis. The aim of the current study was to 
      investigate the possible relation of TNF gene polymorphisms with TNF-alpha and 
      IL-8 synthesis in heavy drinkers. Nineteen heavy drinkers and 14 healthy control 
      subjects were included in the study. Investigations included (a) polymorphisms in 
      the TNF promoter region at positions -238 (G-->A), -308 (G-->A), -857 (C-->T), 
      and -863 (C-->A), as well as a biallelic Ncol restriction fragment length 
      polymorphism in the first intron of the close TNF-beta gene; (b) serum TNF-alpha 
      and IL-8 concentrations; and (c) TNF-alpha and IL-8 production by 
      phytohemagglutinin A-stimulated peripheral blood mononuclear cells. In comparison 
      with findings for control subjects, heavy drinkers showed higher TNF-alpha 
      production, higher IL-8 production, and higher serum IL-8 concentrations. 
      Increased serum TNF-alpha concentrations were specifically found in heavy 
      drinkers with the -857 (C-->T) substitution (CT heterozygotes), therefore 
      indicating an interaction between alcohol consumption and that polymorphism on 
      serum TNF-alpha concentrations.
FAU - Gonzalez-Quintela, Arturo
AU  - Gonzalez-Quintela A
AD  - Department of Internal Medicine, Complejo Hospitalario Universitario de Santiago, 
      Spain. mearturo@usc.es
FAU - Dominguez-Santalla, Maria-Jesus
AU  - Dominguez-Santalla MJ
FAU - Loidi, Lourdes
AU  - Loidi L
FAU - Quinteiro, Celsa
AU  - Quinteiro C
FAU - Perez, Luis F
AU  - Perez LF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alcohol Drinking/*blood/*genetics
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Interleukin-8/*biosynthesis/blood
MH  - Leukocytes, Mononuclear/metabolism
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/*genetics
EDAT- 2005/05/21 09:00
MHDA- 2005/07/12 09:00
CRDT- 2005/05/21 09:00
PHST- 2005/05/21 09:00 [pubmed]
PHST- 2005/07/12 09:00 [medline]
PHST- 2005/05/21 09:00 [entrez]
AID - S0741-8329(04)00164-8 [pii]
AID - 10.1016/j.alcohol.2004.06.011 [doi]
PST - ppublish
SO  - Alcohol. 2004 Oct-Nov;34(2-3):273-7. doi: 10.1016/j.alcohol.2004.06.011.