PMID- 15904961
OWN - NLM
STAT- MEDLINE
DCOM- 20070719
LR  - 20071214
IS  - 1532-2742 (Electronic)
IS  - 0163-4453 (Linking)
VI  - 52
IP  - 2
DP  - 2006 Feb
TI  - Lack of effect of fluoroquinolone resistance on mortality in subjects with 
      Pseudomonas aeruginosa bacteraemia.
PG  - 105-10
AB  - OBJECTIVES: Despite the well-documented increase in fluoroquinolone resistance to 
      Pseudomonas aeruginosa, the effect on pathogenicity is unknown. This paper will 
      explore the clinical effect. METHODS: A retrospective, observational, cohort 
      study of 215 hospital inpatients was performed. Subjects with 
      fluoroquinolone-resistant P. aeruginosa (FQRPA) bacteraemia were compared to 
      subjects with fluoroquinolone-sensitive P. aeruginosa (FQSPA) bacteraemia from 
      January 2000 to December 2003. Mortality prior to discharge, time to discharge, 
      and time to negative culture were assessed. Additionally, baseline 
      morbidity/mortality risk factors including Charlson morbidity score (CMS) were 
      assessed. RESULTS: Mortality prior to discharge (32 vs. 29%, P=0.73), mean days 
      to discharge (17.5 vs. 14.6, P=0.24), and mean days to negative culture (3.6 vs. 
      3.2, P=0.1) did not differ between FQRPA and FQSPA, respectively. Active 
      antibiotic treatment within 24h of drawn blood culture (FQRPA 63% vs. FQSPA 93%, 
      P<0.0001) and median CMS (FQRPA 3 vs. FQSPA 5, P=0.004) differed significantly 
      between the groups. CONCLUSIONS: Subjects with FQRPA received active antibiotics 
      less often within 24h of obtained culture. A large difference in mortality does 
      not likely exist based on fluoroquinolone susceptibility. A study with greater 
      enrollment must be conducted to determine if fluoroquinolone resistance imparts a 
      smaller yet clinically significant impact on clinical outcomes.
FAU - Scheetz, Marc H
AU  - Scheetz MH
AD  - Department of Pharmacy, Northwestern Memorial Hospital, 251 East Huron Street, 
      Feinberg Pavilion LC-700, Chicago, IL 60611, USA. mscheetz@nmh.org
FAU - Bolon, Maureen K
AU  - Bolon MK
FAU - Scarsi, Kimberly K
AU  - Scarsi KK
FAU - Fotis, Michael A
AU  - Fotis MA
FAU - Postelnick, Michael J
AU  - Postelnick MJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
RN  - 0 (Fluoroquinolones)
SB  - IM
MH  - Bacteremia/*drug therapy/microbiology/*mortality
MH  - Cohort Studies
MH  - Female
MH  - Fluoroquinolones/*pharmacology/therapeutic use
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Pseudomonas Infections/*drug therapy/*mortality
MH  - Pseudomonas aeruginosa/*drug effects
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2005/05/21 09:00
MHDA- 2007/07/20 09:00
CRDT- 2005/05/21 09:00
PHST- 2005/01/27 00:00 [received]
PHST- 2005/03/22 00:00 [accepted]
PHST- 2005/05/21 09:00 [pubmed]
PHST- 2007/07/20 09:00 [medline]
PHST- 2005/05/21 09:00 [entrez]
AID - S0163-4453(05)00080-0 [pii]
AID - 10.1016/j.jinf.2005.03.007 [doi]
PST - ppublish
SO  - J Infect. 2006 Feb;52(2):105-10. doi: 10.1016/j.jinf.2005.03.007.