PMID- 15907942
OWN - NLM
STAT- MEDLINE
DCOM- 20050822
LR  - 20231120
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 233
IP  - 1-2
DP  - 2005 Jun 15
TI  - Neural stem cells as a potential source of oligodendrocytes for myelin repair.
PG  - 179-81
AB  - Neural stem cells (NSCs) are considered to have widespread therapeutic 
      possibilities on account of their ability to provide large numbers of cells 
      whilst retaining multi-potentiality. Application to human demyelinating diseases 
      requires improved understanding of the signalling requirements underlying the 
      generation of oligodendrocytes from NSCs. During development, spinal cord 
      oligodendrocyte precursors (OPCs) originate from the ventral, but not dorsal 
      neuroepithelium due to the regulatory effects of the morphogen Sonic hedgehog 
      (Shh). The developing human spinal cord shows comparable ventral-dorsal gradient 
      of oligodendrocyte differentiation potential to the embryonic rodent spinal cord. 
      In contrast expanded human neural precursors derived from both isolated ventral 
      or dorsal cultures show a reduced capacity to generate oligodendrocytes, whereas 
      comparable rodent cultures demonstrate a marked increase in oligodendrocyte 
      formation by a hedgehog independent pathway. Inter-species difference in the 
      capacity of neural precursors to generate oligodendrocytes emphasises the need 
      for greater study of human derived stem cell populations.
FAU - Chandran, Siddharthan
AU  - Chandran S
AD  - Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. 
      sc222@cam.ac.uk
FAU - Compston, Alastair
AU  - Compston A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Demyelinating Diseases/*therapy
MH  - Humans
MH  - Myelin Sheath/*metabolism
MH  - Neurons/cytology/*transplantation
MH  - Oligodendroglia/*physiology
MH  - Stem Cells/*physiology
MH  - Wound Healing/physiology
RF  - 33
EDAT- 2005/05/24 09:00
MHDA- 2005/08/23 09:00
CRDT- 2005/05/24 09:00
PHST- 2005/05/24 09:00 [pubmed]
PHST- 2005/08/23 09:00 [medline]
PHST- 2005/05/24 09:00 [entrez]
AID - S0022-510X(05)00103-6 [pii]
AID - 10.1016/j.jns.2005.03.019 [doi]
PST - ppublish
SO  - J Neurol Sci. 2005 Jun 15;233(1-2):179-81. doi: 10.1016/j.jns.2005.03.019.