PMID- 15908974
OWN - NLM
STAT- MEDLINE
DCOM- 20050922
LR  - 20171116
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 36
IP  - 2
DP  - 2005 Jul
TI  - Donor CD31 genotype and its association with acute graft-versus-host disease in 
      HLA identical sibling stem cell transplantation.
PG  - 151-6
AB  - CD31 gene polymorphisms are implicated in the pathogenesis of graft-versus-host 
      disease (GvHD) following haematopoietic stem cell transplantation (HST). We 
      investigated the influence of CD31 genotype on the incidence of GvHD following 
      HST from an human leukocyte antigen (HLA)-identical sibling donor. Donor and 
      recipient CD31 codons 125, 563 and 670 DNA polymorphisms were determined in 85 
      cases of HLA identical sibling HST from two transplant centres. A correlation 
      between CD31 genotype and acute GvHD was considered significant if observed in 
      patients from both transplant centres independently. A strong correlation was 
      identified between donor CD31 codon 125 genotype and the incidence of acute GvHD. 
      Acute GvHD grades II-IV occurred in 27 of 46 (59%) recipients with a CD31 codon 
      125 leucine / valine heterozygous donor compared to nine of 39 (23%) recipients 
      with a CD31 codon 125 homozygous donor (P=0.0019, relative-risk 2.45, 95% 
      confidence interval 1.3-4.5). This correlation was significant in patients from 
      both transplant centres (P=0.015 and P=0.019). We suggest that CD31 genotype may 
      influence the function of donor-derived leukocytes and may be informative when 
      there is a choice of comparable donors.
FAU - Goodman, R S
AU  - Goodman RS
AD  - Tissue Typing Laboratory, Addenbrooke's Cambridge University Teaching Hospital 
      Trust, Cambridge, UK. reyna.goodman@addenbrookes.nhs.uk
FAU - Ewing, J
AU  - Ewing J
FAU - Evans, P C
AU  - Evans PC
FAU - Craig, J
AU  - Craig J
FAU - Poulton, K
AU  - Poulton K
FAU - Dyer, P A
AU  - Dyer PA
FAU - Marcus, R E
AU  - Marcus RE
FAU - Taylor, C J
AU  - Taylor CJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (Codon)
RN  - 0 (Platelet Endothelial Cell Adhesion Molecule-1)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Amino Acid Substitution/genetics
MH  - Codon/*genetics
MH  - Cohort Studies
MH  - Female
MH  - Genotype
MH  - Graft vs Host Disease/*genetics
MH  - Hematologic Neoplasms/genetics/therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Heterozygote
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Endothelial Cell Adhesion Molecule-1/*genetics
MH  - *Polymorphism, Genetic
MH  - Siblings
EDAT- 2005/05/24 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/05/24 09:00
PHST- 2005/05/24 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/05/24 09:00 [entrez]
AID - 1705013 [pii]
AID - 10.1038/sj.bmt.1705013 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2005 Jul;36(2):151-6. doi: 10.1038/sj.bmt.1705013.