PMID- 15910392
OWN - NLM
STAT- MEDLINE
DCOM- 20050901
LR  - 20050524
IS  - 1397-3142 (Print)
IS  - 1397-3142 (Linking)
VI  - 9
IP  - 3
DP  - 2005 Jun
TI  - Non-myeloablative allogenic peripheral blood stem cell transplantation in a 
      patient with refractory osteosarcoma.
PG  - 342-5
AB  - The prognosis of patients with relapsed osteosarcoma is dismal despite the use of 
      intensive chemotherapy. We describe a patient with refractory osteosarcoma who 
      underwent non-myeloablative peripheral blood stem cell transplantation (PBSCT) 
      from an human leukocyte antigen (HLA)-identical sibling during a third complete 
      remission. The patient suffered pulmonary relapse after the transplantation. 
      Cyclosporin A withdrawal induced a graft-vs.-osteosarcoma effect and 
      graft-vs.-host disease, but eventually the tumor progressed. Although our 
      experience in this case suggested the presence of a graft-vs.-osteosarcoma effect 
      during non-myeloablative allogenic PBSCT, this strategy might have limited value 
      for refractory osteosarcoma with rapid growth kinetics.
FAU - Kounami, Shinji
AU  - Kounami S
AD  - Department of Pediatrics, Wakayama Medical University, Wakayama City, Japan. 
      nami@mail.wakayama-med.ac.jp
FAU - Nakayama, Keiko
AU  - Nakayama K
FAU - Yoshiyama, Megumi
AU  - Yoshiyama M
FAU - Yoshimasu, Tetsu
AU  - Yoshimasu T
FAU - Aoyagi, Noriyuki
AU  - Aoyagi N
FAU - Yoshikawa, Norishige
AU  - Yoshikawa N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
SB  - IM
MH  - Adolescent
MH  - Bone Neoplasms/drug therapy/pathology/*surgery
MH  - Chronic Disease
MH  - Disease Progression
MH  - Fatal Outcome
MH  - Graft vs Host Disease
MH  - Humans
MH  - Lung Neoplasms/secondary
MH  - Male
MH  - Osteosarcoma/drug therapy/pathology/*surgery
MH  - Peripheral Blood Stem Cell Transplantation/methods
MH  - Treatment Failure
EDAT- 2005/05/25 09:00
MHDA- 2005/09/02 09:00
CRDT- 2005/05/25 09:00
PHST- 2005/05/25 09:00 [pubmed]
PHST- 2005/09/02 09:00 [medline]
PHST- 2005/05/25 09:00 [entrez]
AID - PTR290 [pii]
AID - 10.1111/j.1399-3046.2005.00290.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2005 Jun;9(3):342-5. doi: 10.1111/j.1399-3046.2005.00290.x.