PMID- 15910513
OWN - NLM
STAT- MEDLINE
DCOM- 20051201
LR  - 20050524
IS  - 0962-1105 (Print)
IS  - 0962-1105 (Linking)
VI  - 14
IP  - 2
DP  - 2005 Jun
TI  - Influence of HLA antigens and OSAS in childhood: a preliminary report.
PG  - 157-62
AB  - Several studies have emphasized the role of familial factors and familial 
      aggregation in increasing susceptibility to obstructive sleep apnea syndrome 
      (OSAS); the aim of the present study was to investigate the possible influence of 
      human leukocyte antigen (HLA) in the development of sleep disordered breathing 
      and OSAS of children. Between January 2000 and January 2003, all the 370 children 
      [193 males; median age: 5.2 years (range: 1-12 years)] with sleep disordered 
      breathing referred to our Center were screened by a 41-item multiple-choice 
      questionnaire. All habitual snores children underwent a polisomnographic 
      evaluation, and those with an apnea/hypopnea index >3 were diagnosed as having 
      OSAS. All children with OSAS or primary snoring were HLA typed for class I and 
      II. According to nocturnal polygraphic monitoring study, 41 patients were 
      diagnosed as having OSAS and 32 as primary snoring. Patients in the two 
      diagnostic groups were homogeneous for demographic and clinical characteristics. 
      HLA-B65 was found to be significantly more expressed in children with sleep 
      disordered breathing as compared with controls (10.5% versus 3.61; Pypc < 0.04) 
      while no difference was found for the other tested antigens. A logistic 
      regression analysis found cough (P < 0.02) and persistent wheeze (P < 0.008) the 
      sole risk factors for OSAS development. Our preliminary data suggest that HLA 
      does not play a key role in the pathogenesis of OSAS, however more studies are 
      needed to clarify this issue.
FAU - Brunetti, Luigia
AU  - Brunetti L
AD  - Clinica Pediatrica 'Maggiore', Dipartimento di Biomedicina dell'Eta Evolutiva, 
      University of Bari, Bari, Italy. rfrancavilla@libero.it
FAU - Francavilla, Ruggiero
AU  - Francavilla R
FAU - Leonardo Miniello, Vito
AU  - Leonardo Miniello V
FAU - Leone, Maddalena
AU  - Leone M
FAU - Rana, Michele
AU  - Rana M
FAU - Colazzo, Damiano
AU  - Colazzo D
FAU - Logrillo, Paolo
AU  - Logrillo P
FAU - Favoino, Biagio
AU  - Favoino B
FAU - Armenio, Lucio
AU  - Armenio L
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Sleep Res
JT  - Journal of sleep research
JID - 9214441
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genetics, Population
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Infant
MH  - Italy
MH  - Male
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Sleep Apnea, Obstructive/*genetics
MH  - Snoring/genetics
EDAT- 2005/05/25 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/05/25 09:00
PHST- 2005/05/25 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/05/25 09:00 [entrez]
AID - JSR443 [pii]
AID - 10.1111/j.1365-2869.2005.00443.x [doi]
PST - ppublish
SO  - J Sleep Res. 2005 Jun;14(2):157-62. doi: 10.1111/j.1365-2869.2005.00443.x.