PMID- 15914369
OWN - NLM
STAT- MEDLINE
DCOM- 20050729
LR  - 20181113
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 81
IP  - 4
DP  - 2005 May
TI  - Human herpesvirus 6 variant B infection in adult patients after unrelated cord 
      blood transplantation.
PG  - 352-5
AB  - Human herpesvirus 6 variant B (HHV-6B) infection was studied in 23 adult patients 
      who underwent cord blood transplantation (CBT). HHV-6B DNA was detected by 
      quantitative polymerase chain reaction analysis after CBT in the sera from 15 
      patients (65%) at day 14 or 15 (week 2), from 16 patients (70%) at day 21 or 22 
      (week 3), and from 3 patients (13%) at day 28 or 29 (week 4). HHV-6B DNAemia was 
      found in none of the 20 patients examined at day 7 or 8 (week 1). The overall 
      incidence of HHV-6B DNAemia reached 87% (20 of 23 patients). This incidence was 
      much higher than after unrelated bone marrow transplantation (19%, P < .0001). In 
      CBT patients, positive HHV-6B DNAemia at week 3 was significantly associated with 
      early skin rash (88% versus 14%, P < .005) and grade II-IV acute 
      graft-versus-host disease (aGVHD) (69% versus 14%, P < .05). In contrast, 
      positive HHV-6B DNAemia at week 2 was associated with neither skin rash nor 
      aGVHD. Prospective large-scale studies are needed to determine the role of HHV-6 
      infection in CBT patients.
FAU - Tomonari, Akira
AU  - Tomonari A
AD  - Department of Hematology/Oncology, The Institute of Medical Science, The 
      University of Tokyo, Tokyo 108-8639, Japan. atomonar@ims.u-tokyo.ac.jp
FAU - Takahashi, Satoshi
AU  - Takahashi S
FAU - Ooi, Jun
AU  - Ooi J
FAU - Iseki, Tohru
AU  - Iseki T
FAU - Takasugi, Kashiya
AU  - Takasugi K
FAU - Uchiyama, Michihiro
AU  - Uchiyama M
FAU - Konuma, Takaaki
AU  - Konuma T
FAU - Futami, Muneyoshi
AU  - Futami M
FAU - Ohno, Nobuhiro
AU  - Ohno N
FAU - Uchimaru, Kaoru
AU  - Uchimaru K
FAU - Tojo, Arinobu
AU  - Tojo A
FAU - Asano, Shigetaka
AU  - Asano S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cord Blood Stem Cell Transplantation/*adverse effects
MH  - DNA, Viral/analysis
MH  - Female
MH  - Graft vs Host Disease
MH  - Hematologic Neoplasms/therapy
MH  - Herpesvirus 6, Human/*pathogenicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Roseolovirus Infections/*etiology
MH  - Transplantation, Homologous
EDAT- 2005/05/26 09:00
MHDA- 2005/07/30 09:00
CRDT- 2005/05/26 09:00
PHST- 2005/05/26 09:00 [pubmed]
PHST- 2005/07/30 09:00 [medline]
PHST- 2005/05/26 09:00 [entrez]
AID - RRJFWBYXET907EAJ [pii]
AID - 10.1532/IJH97.04183 [doi]
PST - ppublish
SO  - Int J Hematol. 2005 May;81(4):352-5. doi: 10.1532/IJH97.04183.