PMID- 15916810
OWN - NLM
STAT- MEDLINE
DCOM- 20051019
LR  - 20090928
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 87
IP  - 1
DP  - 2005 Jul
TI  - Contributing factors to changes of cerebral blood flow in major depressive 
      disorder.
PG  - 57-63
AB  - BACKGROUND: Results of single photon emission computed tomography (SPECT) 
      regarding mood disorders have been inconsistent. The aim of the study was to 
      elucidate factors contributing to changes in cerebral blood flow in patients with 
      major depressive disorder. METHODS: A total of 89 consecutive patients diagnosed 
      with major depressive disorder using DSM-IV semistructured interviews were 
      evaluated using single photon emission computed tomography, the 17-item Hamilton 
      Rating Scale for Depression (HRSD), and the Global Assessment of Function (GAF) 
      scale. Nineteen of these patients also underwent the same tests during remission. 
      RESULTS: Global cerebral blood flow (gCBF) was significantly higher during 
      remission than at the time of enrollment. Significant correlations were seen 
      between gCBF and age, duration of previous episode of depression, and 
      hypochondriasis. However, no correlation was seen between gCBF and HRSD, GAF, 
      severity and duration of depressive episode, or melancholia-type depression. 
      Correlations between gCBF and age were seen only at enrollment and disappeared 
      during remission. No differences in regional cerebral blood flow at any site were 
      seen between time of enrollment and remission for the same patient. LIMITATION: 
      Analysis that adequately accounts for these factors to changes of cerebral blood 
      flow in major depressive disorder will require a large subject population. 
      CONCLUSIONS: These results suggest that although there is a decrease in gCBF in 
      major depressive disorder, the level of the decrease is determined by conditions 
      present before episode onset, rather than by the characteristics of the episode 
      itself. The findings also suggest that the correlation between gCBF and age is 
      state-dependent.
FAU - Ohgami, Hirochika
AU  - Ohgami H
AD  - Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, 
      Oita 879-5593, Japan. OOGAMI@med.oita-u.ac.jp
FAU - Nagayama, Haruo
AU  - Nagayama H
FAU - Akiyoshi, Jotaro
AU  - Akiyoshi J
FAU - Tsuchiyama, Kounosuke
AU  - Tsuchiyama K
FAU - Komaki, Shogo
AU  - Komaki S
FAU - Takaki, Hajime
AU  - Takaki H
FAU - Mori, Hiromu
AU  - Mori H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cerebral Cortex/*blood supply
MH  - Depressive Disorder, Major/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Recurrence
MH  - Regional Blood Flow
MH  - Severity of Illness Index
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 2005/05/27 09:00
MHDA- 2005/10/20 09:00
CRDT- 2005/05/27 09:00
PHST- 2004/09/22 00:00 [received]
PHST- 2005/03/03 00:00 [accepted]
PHST- 2005/05/27 09:00 [pubmed]
PHST- 2005/10/20 09:00 [medline]
PHST- 2005/05/27 09:00 [entrez]
AID - S0165-0327(05)00077-7 [pii]
AID - 10.1016/j.jad.2005.03.004 [doi]
PST - ppublish
SO  - J Affect Disord. 2005 Jul;87(1):57-63. doi: 10.1016/j.jad.2005.03.004.