PMID- 15924994
OWN - NLM
STAT- MEDLINE
DCOM- 20050823
LR  - 20161124
IS  - 0141-1136 (Print)
IS  - 0141-1136 (Linking)
VI  - 60
IP  - 4
DP  - 2005 Oct
TI  - Evaluation of the relationships between biochemical endpoints of PAH exposure and 
      physiological endpoints of reproduction in male California Halibut (Paralichthys 
      californicus) exposed to sediments from a natural oil seep.
PG  - 454-65
AB  - Coal Oil Point (COP) is a natural oil seep off the coast of Santa Barbara, 
      California. Although most studies examining the fate and effects of petroleum 
      have focused upon urbanized or anthropogenic sources of inputs, few have examined 
      the effects of polyaromatic hydrocarbons (PAHs) derived from natural seeps. In 
      order to evaluate the effects of PAHs derived from COP on marine fish 
      populations, hatchery-reared California Halibut (Platichthys californicus) were 
      exposed for 30 days to seven dilutions of sediments collected from COP. Hepatic 
      cytochrome P450 1A (CYP1A), biliary fluorescent aromatic compounds (FACs), 
      gonadal somatic indices, and plasma steroid concentrations. Sixteen USEPA 
      priority PAHs were targeted for analysis in each sediment dilution. In general, 
      biochemical responses were somewhat recalcitrant to dose-response relationships 
      and were less sensitive than the literature values established for the same 
      indicators following exposure to urbanized PAHs. Trends toward reductions in 
      plasma 17beta-estradiol concentrations were observed, but reductions in gonadal 
      somatic indices were not observed. FAC values for naphthalene, benzo(a)pyrene, 
      phenanthrene-related compounds reached maximums at 33-100% COP sediment. The 
      resulting insensitivity may be unique for exposure to "natural" petroleum due to 
      a higher concentration of lower molecular weight PAHs or uncharacterized 
      inhibitors.
FAU - Seruto, Cherlynn
AU  - Seruto C
AD  - Department of Environmental Sciences, Environmental Toxicology Program, 
      University of California, Riverside 92521, USA.
FAU - Sapozhnikova, Yelena
AU  - Sapozhnikova Y
FAU - Schlenk, Daniel
AU  - Schlenk D
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20050402
PL  - England
TA  - Mar Environ Res
JT  - Marine environmental research
JID - 9882895
RN  - 0 (Petroleum)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Water Pollutants, Chemical)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - *Environmental Exposure
MH  - Estradiol/blood
MH  - Flounder/*physiology
MH  - Geological Phenomena
MH  - Geology
MH  - Male
MH  - Petroleum
MH  - Polycyclic Aromatic Hydrocarbons/*poisoning
MH  - Testis/cytology
MH  - Water Pollutants, Chemical/*poisoning
EDAT- 2005/06/01 09:00
MHDA- 2005/08/24 09:00
CRDT- 2005/06/01 09:00
PHST- 2004/10/26 00:00 [received]
PHST- 2005/01/06 00:00 [revised]
PHST- 2005/01/25 00:00 [accepted]
PHST- 2005/06/01 09:00 [pubmed]
PHST- 2005/08/24 09:00 [medline]
PHST- 2005/06/01 09:00 [entrez]
AID - S0141-1136(05)00012-7 [pii]
AID - 10.1016/j.marenvres.2005.01.004 [doi]
PST - ppublish
SO  - Mar Environ Res. 2005 Oct;60(4):454-65. doi: 10.1016/j.marenvres.2005.01.004. 
      Epub 2005 Apr 2.