PMID- 15925034
OWN - NLM
STAT- MEDLINE
DCOM- 20051011
LR  - 20191210
IS  - 0301-0511 (Print)
IS  - 0301-0511 (Linking)
VI  - 69
IP  - 3
DP  - 2005 Jul
TI  - Event-related potentials (ERPs) in ecstasy (MDMA) users during a visual oddball 
      task.
PG  - 333-52
AB  - Ecstasy is the common name for a drug mainly containing a substance identified as 
      3,4-methylenedioxymethamphetamine (MDMA). It has become popular with participants 
      in "raves", because it enhances energy, endurance and sexual arousal, together 
      with the widespread belief that MDMA is a safe drug [Byard, R.W., Gilbert, J., 
      James, R., Lokan, R.J., 1998. Amphetamine derivative fatalities in South 
      Australia. Is "ecstasy" the culprit? Am. J. Forensic Med. Pathol. 19, 261-265]. 
      However, it is suggested that this drug causes a neurotoxicity to the 
      serotonergic system that could lead to permanent physical and cognitive problems. 
      In order to investigate this issue, and during an ERP recording with 32 channels, 
      we used a visual oddball design, in which subjects (14 MDMA abusers and 14 paired 
      normal controls) saw frequent stimuli (neutral faces) while they had to detect as 
      quickly as possible rare stimuli with happy or fearful expression. At a 
      behavioral level, MDMA users imply longer latencies than normal controls to 
      detect rare stimuli. At the neurophysiological level, ERP data suggest as main 
      result that the N200 component, which is involved in attention orienting 
      associated to the detection of stimulus novelty (e.g. [Campanella, S., Gaspard, 
      C., Debatisse, D., Bruyer, R., Crommelinck, M., Guerit, J.M., 2002. 
      Discrimination of emotional facial expression in a visual oddball task: an ERP 
      study. Biol. Psychol. 59, 171-186]), shows shorter latencies for fearful rare 
      stimuli (as compared to happy ones), but only for normal controls. This absence 
      of delay was interpreted as an attentional deficit due to MDMA consumption.
FAU - Mejias, S
AU  - Mejias S
AD  - Rodin Foundation, Belgium.
FAU - Rossignol, M
AU  - Rossignol M
FAU - Debatisse, D
AU  - Debatisse D
FAU - Streel, E
AU  - Streel E
FAU - Servais, L
AU  - Servais L
FAU - Guerit, J M
AU  - Guerit JM
FAU - Philippot, P
AU  - Philippot P
FAU - Campanella, S
AU  - Campanella S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biol Psychol
JT  - Biological psychology
JID - 0375566
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Anxiety/diagnosis
MH  - Attention/drug effects
MH  - Discrimination, Psychological/drug effects
MH  - Electroencephalography
MH  - Evoked Potentials/*drug effects
MH  - Facial Expression
MH  - Female
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Recognition, Psychology/drug effects
MH  - Surveys and Questionnaires
MH  - *Visual Perception
EDAT- 2005/06/01 09:00
MHDA- 2005/10/12 09:00
CRDT- 2005/06/01 09:00
PHST- 2004/06/28 00:00 [received]
PHST- 2004/11/11 00:00 [accepted]
PHST- 2005/06/01 09:00 [pubmed]
PHST- 2005/10/12 09:00 [medline]
PHST- 2005/06/01 09:00 [entrez]
AID - S0301-0511(04)00186-3 [pii]
AID - 10.1016/j.biopsycho.2004.11.010 [doi]
PST - ppublish
SO  - Biol Psychol. 2005 Jul;69(3):333-52. doi: 10.1016/j.biopsycho.2004.11.010.