PMID- 15926071
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20181113
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 447
IP  - 1
DP  - 2005 Jul
TI  - Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation.
PG  - 99-102
AB  - Bizarre parosteal osteochondromatous proliferation (BPOP) is a benign lesion that 
      tends to recur repeatedly. Histologically, BPOP contains three components 
      (cartilage, bone, and spindle cells) in differing amounts. The histological 
      findings of BPOP are similar to those of florid reactive periostitis (FRP) and 
      subungual (Dupuytren's) exostosis. Some authors have postulated that all of these 
      conditions are reactive proliferative lesions representing different phases of 
      reactive processes. Whether BPOP is a reactive proliferative lesion or a 
      neoplastic lesion, however, remains controversial. Recently, a t(1;17)(q32;q21) 
      translocation in BPOP was detected using chromosome banding and fluorescence in 
      situ hybridization (FISH) analyses. Here, we describe a 39-year-old Japanese 
      female with BPOP arising in the proximal phalanx of her third toe. A cytogenetic 
      analysis revealed a t(1;17)(q 42;q23) translocation. The breakpoints in this case 
      are located close to those of previously reported cases. These results suggest 
      that t(1;17) is a distinct translocation of BPOP and that BPOP is a neoplastic 
      lesion, rather than a reactive proliferative process.
FAU - Endo, Makoto
AU  - Endo M
AD  - Division of Orthopaedic Oncology, National Cancer Centre Hospital and Research 
      Institute, Tokyo, Japan.
FAU - Hasegawa, Tadashi
AU  - Hasegawa T
FAU - Tashiro, Takashi
AU  - Tashiro T
FAU - Yamaguchi, Umio
AU  - Yamaguchi U
FAU - Morimoto, Yuki
AU  - Morimoto Y
FAU - Nakatani, Fumihiko
AU  - Nakatani F
FAU - Shimoda, Tadakazu
AU  - Shimoda T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20050531
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
SB  - IM
MH  - Adult
MH  - Bone Neoplasms/*genetics/pathology/surgery
MH  - Cell Proliferation
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Osteochondroma/*genetics/pathology/surgery
MH  - Radiography
MH  - Spectral Karyotyping
MH  - Toes/diagnostic imaging/pathology
MH  - *Translocation, Genetic
MH  - Treatment Outcome
EDAT- 2005/06/01 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/06/01 09:00
PHST- 2005/01/19 00:00 [received]
PHST- 2005/03/30 00:00 [accepted]
PHST- 2005/06/01 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/06/01 09:00 [entrez]
AID - 10.1007/s00428-005-1266-7 [doi]
PST - ppublish
SO  - Virchows Arch. 2005 Jul;447(1):99-102. doi: 10.1007/s00428-005-1266-7. Epub 2005 
      May 31.