PMID- 15927374
OWN - NLM
STAT- MEDLINE
DCOM- 20050923
LR  - 20220310
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 385
IP  - 1
DP  - 2005 Sep 2
TI  - Tumor necrosis factor-alpha --G308A polymorphism in schizophrenia in a Finnish 
      population.
PG  - 76-81
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine with 
      functions in nerve cell growth, differentiation, and apoptosis. There are several 
      studies showing that a TNF-alpha--G308A promoter polymorphism, which possibly 
      affects TNF-alpha transcription, is associated with schizophrenia, although 
      negative results also exist. Our aim was to investigate the relationship between 
      the TNF-alpha --G308A promoter polymorphism, the risk of schizophrenia, and the 
      age of onset of schizophrenia, and the TNF-alpha -G308A polymorphism was 
      therefore studied in 149 southern Finnish patients with a DSM-IV diagnosis of 
      schizophrenia and in 393 healthy controls. The allele and genotype frequencies 
      did not differ significantly between the patient and control groups (P=0.10 and 
      0.12, respectively), but the frequency of G/G homozygotes was statistically 
      significantly higher in male patients than in male controls (chi(2)=5.03, d.f.=1, 
      P=0.025) with an odds ratio of 2.00 (95% confidence interval: 1.08--3.70). No 
      such difference was seen in female patients (P=0.79) or in the whole study group 
      (P=0.064). The age of onset of schizophrenia did not differ significantly between 
      the different TNF-alpha genotypes (ANOVA: F=0.45, P=0.64). In conclusion, we did 
      not find a clear association between the TNF-alpha --G308A polymorphism and 
      schizophrenia in the whole study group. However, TNF-alpha --G308A G/G 
      homozygosity was modestly associated with schizophrenia in male patients.
FAU - Hanninen, Kari
AU  - Hanninen K
AD  - South Karelia Central Hospital, Department of Psychiatry, Valto Kakelan katu 
      14C/6, FIN-53130 Lappeenranta, Finland. kari.hanninen@ekshp.fi
FAU - Katila, Heikki
AU  - Katila H
FAU - Rontu, Riikka
AU  - Rontu R
FAU - Mattila, Kari M
AU  - Mattila KM
FAU - Hurme, Mikko
AU  - Hurme M
FAU - Lehtimaki, Terho
AU  - Lehtimaki T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - Female
MH  - Finland/epidemiology
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Schizophrenia/epidemiology/*genetics
MH  - Sex Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2005/06/02 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/06/02 09:00
PHST- 2005/03/04 00:00 [received]
PHST- 2005/05/06 00:00 [revised]
PHST- 2005/05/07 00:00 [accepted]
PHST- 2005/06/02 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/06/02 09:00 [entrez]
AID - S0304-3940(05)00563-X [pii]
AID - 10.1016/j.neulet.2005.05.023 [doi]
PST - ppublish
SO  - Neurosci Lett. 2005 Sep 2;385(1):76-81. doi: 10.1016/j.neulet.2005.05.023.