PMID- 15927671
OWN - NLM
STAT- MEDLINE
DCOM- 20050816
LR  - 20131121
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 29
IP  - 7
DP  - 2005 Jul
TI  - Induction of CXC and CC chemokines by all-trans retinoic acid in acute 
      promyelocytic leukemia cells.
PG  - 755-9
AB  - We previously reported the induction of interleukin-8 (IL-8), one of the CXC 
      chemokines, by all-trans retinoic acid (ATRA) in PL-21 and NB4 human myeloid 
      leukemia cells, which may be implicated in APL differentiation syndrome that is a 
      relatively frequent complication in patients with acute promyelocytic leukemia 
      (APL) during treatment with ATRA. We, therefore, further investigated the effects 
      of ATRA on the expression of chemokine family in NB4 cells and APL cells prepared 
      from two APL patients. The RNase protection assay using a multi-probe template 
      set for human chemokines revealed that ATRA induced gene expressions of a number 
      of CC chemokines, such as monocyte chemoattractant protein-1 (MCP-1), macrophage 
      inflammatory protein (MIP)-1alpha and MIP-1beta in NB4 cells. Their antigen 
      levels were also increased in the cultured media. APL cells prepared from two APL 
      patients showed gene expression of chemokines, such as IL-8, MCP-1, MIP-1alpha, 
      and MIP-1beta when stimulated with ATRA in vitro. Furthermore, serum levels of 
      IL-8, MIP-1beta and RANTES were increased during the course of ATRA treatment in 
      both APL patients who developed APL differentiation syndrome. These chemokines 
      are all chemoattractants of particular inflammatory cell types, including 
      neutrophils, monocytes and lymphocytes; therefore, the simultaneous induction of 
      these chemokines after stimulation with ATRA may exacerbate the 
      hyper-inflammation observed in ATRA-induced APL differentiation syndrome.
FAU - Shibakura, Misako
AU  - Shibakura M
AD  - Department of Medical Technology, Faculty of Health Sciences, Okayama University 
      Medical School, Okayama 700-8558, Japan. m_shiba@md.okayama-u.ac.jp
FAU - Niiya, Kenji
AU  - Niiya K
FAU - Niiya, Masami
AU  - Niiya M
FAU - Asaumi, Noboru
AU  - Asaumi N
FAU - Yoshida, Chikamasa
AU  - Yoshida C
FAU - Nakata, Yasunari
AU  - Nakata Y
FAU - Tanimoto, Mitsune
AU  - Tanimoto M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050226
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Chemokines, CC)
RN  - 0 (Chemokines, CXC)
RN  - 0 (DNA Primers)
RN  - 0 (Interleukin-8)
RN  - 0 (RNA, Messenger)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Antineoplastic Agents/pharmacology
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Cell Line, Tumor
MH  - Chemokines, CC/*genetics
MH  - Chemokines, CXC/*genetics
MH  - DNA Primers
MH  - Gene Expression Regulation, Neoplastic/*drug effects
MH  - Humans
MH  - Interleukin-8/biosynthesis
MH  - Leukemia, Promyelocytic, Acute
MH  - RNA, Messenger/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tretinoin/*pharmacology
EDAT- 2005/06/02 09:00
MHDA- 2005/08/17 09:00
CRDT- 2005/06/02 09:00
PHST- 2004/05/25 00:00 [received]
PHST- 2005/01/02 00:00 [accepted]
PHST- 2005/06/02 09:00 [pubmed]
PHST- 2005/08/17 09:00 [medline]
PHST- 2005/06/02 09:00 [entrez]
AID - S0145-2126(05)00042-1 [pii]
AID - 10.1016/j.leukres.2005.01.005 [doi]
PST - ppublish
SO  - Leuk Res. 2005 Jul;29(7):755-9. doi: 10.1016/j.leukres.2005.01.005. Epub 2005 Feb 
      26.