PMID- 15928601
OWN - NLM
STAT- MEDLINE
DCOM- 20060428
LR  - 20161021
IS  - 1732-2693 (Electronic)
IS  - 0032-5449 (Linking)
VI  - 59
DP  - 2005 May 6
TI  - [Immune reconstitution syndromes secondary to effective antiretroviral therapy].
PG  - 180-7
AB  - Highly active antiretroviral therapy (HAART) can improve immune system function 
      through suppression of HIV-1 replication. In some cases, a vigorous paradoxical 
      immune response may develop. Individuals treated effectively can, because of low 
      immune reactivity, suffer from diseases which run subclinically until HAART is 
      introduced. These symptoms are termed IRS (immune reconstitution syndrome/immune 
      recovery syndrome), IRD (immune restoration disease), and IRIS (immune 
      restoration inflammatory syndrome). There are some predisposing factors, such as 
      long-lasting HIV-1 infection, severe immunodeficiency, rapid immune restoration, 
      immune dysregulation during immune reconstitution, subclinical infection, and 
      genetic susceptibility. A common feature of IRS is clinical symptoms different 
      from those observed usually in HIV-1-infected patients. Sarcoidosis and some 
      autoimmune diseases are less common. They are present for the first time or as an 
      exacerbation of established diseases. Diagnosis is difficult. It is very often 
      impossible to identify the pathogen. The clinical symptoms in patients receiving 
      HAART should be differentiated into IRS, ineffective HAART leading to the 
      development of opportunistic infection, and drug toxicity.
FAU - Knysz, Brygida
AU  - Knysz B
AD  - Katedra i Klinika Chorob Zakaznych Akademii Medycznej, Wroclaw. 
      brygida@wroclaw.dialog.net.pl
FAU - Rogowska-Szadkowska, Dorota
AU  - Rogowska-Szadkowska D
FAU - Gasiorowski, Jacek
AU  - Gasiorowski J
FAU - Gladysz, Andrzej
AU  - Gladysz A
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Zespoly rekonstrukcji immunologicznej jako nastepstwo skutecznej terapii 
      antyretrowirusowej.
PL  - Poland
TA  - Postepy Hig Med Dosw (Online)
JT  - Postepy higieny i medycyny doswiadczalnej (Online)
JID - 101206517
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/diagnosis/immunology
MH  - Acquired Immunodeficiency Syndrome/drug therapy/immunology
MH  - Anti-HIV Agents/*therapeutic use
MH  - Antiretroviral Therapy, Highly Active
MH  - Diagnosis, Differential
MH  - Humans
MH  - Immune System Diseases/diagnosis/*immunology
MH  - Immune Tolerance/*drug effects/immunology
MH  - Inflammation/diagnosis/immunology
MH  - Recovery of Function/*drug effects/*immunology
MH  - Syndrome
MH  - Systemic Inflammatory Response Syndrome/diagnosis/immunology
RF  - 76
EDAT- 2005/06/02 09:00
MHDA- 2006/04/29 09:00
CRDT- 2005/06/02 09:00
PHST- 2005/01/11 00:00 [received]
PHST- 2005/03/30 00:00 [accepted]
PHST- 2005/06/02 09:00 [pubmed]
PHST- 2006/04/29 09:00 [medline]
PHST- 2005/06/02 09:00 [entrez]
AID - 7291 [pii]
PST - ppublish
SO  - Postepy Hig Med Dosw (Online). 2005 May 6;59:180-7.