PMID- 15929080
OWN - NLM
STAT- MEDLINE
DCOM- 20051115
LR  - 20160303
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 117
IP  - 4
DP  - 2005 Nov 20
TI  - Interaction of host and viral risk factors for development of cervical carcinoma 
      in situ.
PG  - 690-2
AB  - Infection by oncogenic human papillomavirus (HPV) is a necessary but not 
      sufficient cause of cervical carcinoma. Several host genetic and viral factors 
      have been reported to increase the risk of carcinoma development given an HPV 
      infection. In our study, we have analysed the contribution of HPV 16 E6 sequence 
      subtype and allelic variation at human leukocyte antigen (HLA) class II loci to 
      the risk of developing cervical carcinoma in situ. Non-European-like HPV 16 E6 
      sequence subtypes were not found to be associated with an increased risk of 
      cervical carcinoma, as compared to European-like variants. However, an 
      association was found between the HPV 16 E6 L83V variant and the DR*04-DQ*03 
      haplotype. This association has been observed in several independent studies and 
      shows that both the host HLA class II genotype and viral subtype will affect the 
      risk of an infection progressing into cervical carcinoma.
CI  - Copyright 2005 Wiley-Liss, Inc.
FAU - Beskow, Anna H
AU  - Beskow AH
AD  - Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, 
      Sweden.
FAU - Engelmark, Malin T
AU  - Engelmark MT
FAU - Magnusson, Jessica J
AU  - Magnusson JJ
FAU - Gyllensten, Ulf B
AU  - Gyllensten UB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (DNA Primers)
SB  - IM
MH  - Base Sequence
MH  - Carcinoma in Situ/*virology
MH  - Case-Control Studies
MH  - DNA Primers
MH  - Female
MH  - Humans
MH  - Papillomaviridae/*isolation & purification
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Uterine Cervical Neoplasms/*virology
EDAT- 2005/06/02 09:00
MHDA- 2005/11/16 09:00
CRDT- 2005/06/02 09:00
PHST- 2005/06/02 09:00 [pubmed]
PHST- 2005/11/16 09:00 [medline]
PHST- 2005/06/02 09:00 [entrez]
AID - 10.1002/ijc.21212 [doi]
PST - ppublish
SO  - Int J Cancer. 2005 Nov 20;117(4):690-2. doi: 10.1002/ijc.21212.