PMID- 15929104
OWN - NLM
STAT- MEDLINE
DCOM- 20050816
LR  - 20171116
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 79
IP  - 2
DP  - 2005 Jun
TI  - Variant lymphoproliferative disorder of granular lymphocytes (LDGL) following 
      Hodgkin lymphoma.
PG  - 128-31
AB  - A 41-year-old Caucasian female was diagnosed with a CD3(+) CD4(+) CD8(+) variant 
      of lymphoproliferative disorder of granular lymphocytes (LDGL) in the third year 
      of remission following treatment of stage III-B Hodgkin lymphoma (HL). The 
      patient was asymptomatic at diagnosis, without clinical evidence of immune 
      disorder or recurrence of HL. Diagnosis was made incidentally, secondary to 
      lymphocytosis discovered on a routine follow-up post HL therapy. Clonal 
      chromosomal abnormalities were seen in 20% of peripheral blood lymphocytes with a 
      karyotype 46, XX, t(2;6;2;11) (p13;q23;q24;q23). The breakpoint on 11q23 is 
      distal to the MLL gene as shown by fluorescence in situ hybridization (FISH) 
      analysis. To our knowledge, this is the first report of variant LDGL in 
      association with HL treatment with documented clonal chromosomal abnormalities.
FAU - Jenkins, Brian Douglas
AU  - Jenkins BD
AD  - The Van Elslander Cancer Center, St. John Hospital and Medical Center, Detroit, 
      Michigan 48236, USA.
FAU - Snower, Daniel
AU  - Snower D
FAU - Mohamed, Anwar
AU  - Mohamed A
FAU - Al-Katib, Ayad
AU  - Al-Katib A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (CD3 Complex)
RN  - 11056-06-7 (Bleomycin)
RN  - 5V9KLZ54CY (Vinblastine)
RN  - 7GR28W0FJI (Dacarbazine)
RN  - 80168379AG (Doxorubicin)
RN  - ABVD protocol
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/*adverse effects/therapeutic use
MH  - Bleomycin/*adverse effects/therapeutic use
MH  - CD3 Complex/metabolism
MH  - CD4-Positive T-Lymphocytes/pathology
MH  - CD8-Positive T-Lymphocytes/pathology
MH  - Chromosome Aberrations
MH  - Cytogenetic Analysis
MH  - Dacarbazine/*adverse effects/therapeutic use
MH  - Doxorubicin/*adverse effects/therapeutic use
MH  - Female
MH  - Granulocytes/*pathology
MH  - Hodgkin Disease/diagnosis/*drug therapy/pathology
MH  - Humans
MH  - Lymphocytosis/chemically induced/pathology
MH  - Lymphoproliferative Disorders/*blood/*chemically induced/genetics
MH  - Neoplasm Staging
MH  - Phenotype
MH  - T-Lymphocytes/metabolism/*pathology
MH  - Vinblastine/*adverse effects/therapeutic use
EDAT- 2005/06/02 09:00
MHDA- 2005/08/17 09:00
CRDT- 2005/06/02 09:00
PHST- 2005/06/02 09:00 [pubmed]
PHST- 2005/08/17 09:00 [medline]
PHST- 2005/06/02 09:00 [entrez]
AID - 10.1002/ajh.20312 [doi]
PST - ppublish
SO  - Am J Hematol. 2005 Jun;79(2):128-31. doi: 10.1002/ajh.20312.