PMID- 15932374
OWN - NLM
STAT- MEDLINE
DCOM- 20051011
LR  - 20051116
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 60
IP  - 7
DP  - 2005 Jul
TI  - Controlled oral food challenges in children--when indicated, when superfluous?
PG  - 865-70
AB  - The diagnostic work-up of suspected food allergy includes the skin prick test 
      (SPT), the measurement of food specific immunoglobulin E (IgE) antibodies using 
      serologic assays, and more recently the atopy patch test (APT). For specific 
      serum IgE and the SPT, decision points have been established for some foods 
      allowing prediction of clinical relevance in selected cases. The APT may be 
      helpful, especially when considered in combination with defined levels of 
      specific IgE. Controlled oral food challenges still remain the gold standard in 
      the diagnostic work-up of children with suspected food allergy. Most food 
      allergic children will lose their allergy over time. As there is no laboratory 
      parameter, which can accurately predict when clinical tolerance has been 
      developed, controlled oral food challenges are the measure of choice. In this 
      article, the current knowledge of predictors for the outcome of oral food 
      challenges is reviewed and proposals for the daily practical work-up in the case 
      of suspected food related clinical symptoms are presented.
FAU - Niggemann, B
AU  - Niggemann B
AD  - Department of Pediatric Pneumology and Immunology, University Children's Hospital 
      Charite of Humboldt University, Berlin, Germany.
FAU - Rolinck-Werninghaus, C
AU  - Rolinck-Werninghaus C
FAU - Mehl, A
AU  - Mehl A
FAU - Binder, C
AU  - Binder C
FAU - Ziegert, M
AU  - Ziegert M
FAU - Beyer, K
AU  - Beyer K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Algorithms
MH  - *Diagnostic Techniques and Procedures
MH  - Food/*adverse effects
MH  - Food Hypersensitivity/blood/*diagnosis/immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Predictive Value of Tests
MH  - Skin Tests
RF  - 45
EDAT- 2005/06/04 09:00
MHDA- 2005/10/12 09:00
CRDT- 2005/06/04 09:00
PHST- 2005/06/04 09:00 [pubmed]
PHST- 2005/10/12 09:00 [medline]
PHST- 2005/06/04 09:00 [entrez]
AID - ALL828 [pii]
AID - 10.1111/j.1398-9995.2005.00828.x [doi]
PST - ppublish
SO  - Allergy. 2005 Jul;60(7):865-70. doi: 10.1111/j.1398-9995.2005.00828.x.