PMID- 1593429
OWN - NLM
STAT- MEDLINE
DCOM- 19920702
LR  - 20190819
IS  - 0886-3350 (Print)
IS  - 0886-3350 (Linking)
VI  - 18
IP  - 3
DP  - 1992 May
TI  - Fibrinous reaction on implanted intraocular lenses. A comparison of conventional 
      PMMA and heparin surface modified lenses.
PG  - 236-9
AB  - We studied the fibrinous reaction after intraocular lens (IOL) implantation in 
      the posterior chamber of cynomolgus monkeys. In 50% of the eyes, we implanted an 
      IOL made of conventional poly-(methyl methacrylate) (PMMA); in the remaining eyes 
      we implanted a PMMA IOL with a heparin modified surface. Two, 4, 8, and 18 weeks 
      after surgery the eyes were examined by slitlamp for fibrinous reactions on and 
      around the IOL surface. At weeks 4, 8, and 18 there was a marked decrease in 
      fibrinous reaction in the eyes with a heparin surface modified IOL. The results 
      of this study accord with earlier findings that heparin surface modification 
      improves the biocompatibility of the IOL.
FAU - Lundgren, B
AU  - Lundgren B
AD  - Kabi Pharmacia Ophthalmics, Department of Biology, Uppsala, Sweden.
FAU - Selen, G
AU  - Selen G
FAU - Spangberg, M
AU  - Spangberg M
FAU - Harfstrand, A
AU  - Harfstrand A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
RN  - 0 (Methylmethacrylates)
RN  - 9001-31-4 (Fibrin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Cataract Extraction
MH  - Female
MH  - Fibrin/*biosynthesis
MH  - Foreign-Body Reaction/metabolism
MH  - *Heparin
MH  - *Lenses, Intraocular
MH  - Macaca fascicularis
MH  - Male
MH  - *Methylmethacrylates
MH  - Surface Properties
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - S0886-3350(13)80899-1 [pii]
AID - 10.1016/s0886-3350(13)80899-1 [doi]
PST - ppublish
SO  - J Cataract Refract Surg. 1992 May;18(3):236-9. doi: 
      10.1016/s0886-3350(13)80899-1.