PMID- 15934838
OWN - NLM
STAT- MEDLINE
DCOM- 20060406
LR  - 20191026
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 5
IP  - 5
DP  - 2005 May
TI  - Haematopoietic stem cell transplantation to treat aplastic anaemia.
PG  - 617-26
AB  - Aplastic anaemia (AA) consists of pancytopenia and empty bone marrow. Its 
      incidence varies worldwide but predominates in developing countries. Diverse 
      aetiologies are involved, with autoimmunity at the centre of the picture. For the 
      70% of patients with the severe and very severe forms of AA and who lack a human 
      leukocyte antigen (HLA)-matched sibling, immunosuppressive therapy (IST) is key 
      in treating the disease, with a remission rate close to 70%, an 80-90% 5-year 
      survival rate in responding patients and a relapse rate close to 10%. For the 30% 
      with a sibling donor available, haematopoietic stem cell transplant (HSCT) from 
      bone marrow or peripheral blood has up to a 90% chance of cure, with a 5-10% 
      graft rejection/failure rate. Patients who fail IST (25-30%) and lack a sibling 
      donor can benefit from CD34(+)-enriched, partially T cell-depleted unrelated stem 
      cell transplants, with a general survival rate up to 37%, the newest source of 
      stem cells for this modality being cord blood. Non-myeloablative, 
      irradiation-free conditioning regimens offer appreciable benefits, and new 
      immunosuppressive agents, such as fludarabine and alemtuzumab, have been 
      incorporated with promising preliminary results. Graft-versus-host disease, graft 
      failure and infections remain significant challenges in HSCT for which innovative 
      treatment strategies are being developed at present.
FAU - Jaime-Perez, Jose C
AU  - Jaime-Perez JC
AD  - Universidad Autonoma de Nuevo Leon Servicio de Hematologia, Hospital 
      Universitario, Dr Jose E. Gonzalez, Edificio Dr Rodrigo Barragan, 2 piso., 
      Avenida Madero y Gonzalitos, Monterrey, Nuevo Leon, C.P. 64460, Mexico. 
      carjaime@hotmail.com
FAU - Ruiz-Arguelles, Guillermo J
AU  - Ruiz-Arguelles GJ
FAU - Gomez-Almaguer, David
AU  - Gomez-Almaguer D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
SB  - IM
MH  - Anemia, Aplastic/blood/*surgery
MH  - Animals
MH  - Clinical Trials as Topic/statistics & numerical data
MH  - Graft Rejection/blood/prevention & control
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Transplantation Conditioning/*methods
RF  - 78
EDAT- 2005/06/07 09:00
MHDA- 2006/04/07 09:00
CRDT- 2005/06/07 09:00
PHST- 2005/06/07 09:00 [pubmed]
PHST- 2006/04/07 09:00 [medline]
PHST- 2005/06/07 09:00 [entrez]
AID - 10.1517/14712598.5.5.617 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2005 May;5(5):617-26. doi: 10.1517/14712598.5.5.617.