PMID- 15934845
OWN - NLM
STAT- MEDLINE
DCOM- 20060406
LR  - 20191026
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 5
IP  - 5
DP  - 2005 May
TI  - Dendritic cell fusion vaccines for cancer immunotherapy.
PG  - 703-15
AB  - The use of tumour vaccines is being explored as a means of generating effective 
      antitumour immune responses in patients with cancer. Dendritic cells (DCs) are 
      the most potent antigen-presenting cells that are essential for initiating 
      primary immune responses. As such, DCs are being studied as a platform for the 
      design of cancer vaccines. DCs loaded with tumour antigens or whole tumour cell 
      derivatives stimulate tumour-specific immunity. A promising vaccine strategy 
      involves the fusion of DCs with whole tumour cells. DC/tumour fusions express a 
      broad array of tumour antigens, including those yet to be identified, in the 
      context of DC-mediated costimulation. Animal models have demonstrated that 
      vaccination with fusion cells is protective against tumour challenge and results 
      in the regression of established metastatic disease. In vitro human studies have 
      demonstrated that DC/tumour fusions potently stimulate antitumour immunity and 
      lysis of autologous tumour cells. Vaccination of cancer patients with DC/tumour 
      fusions is being studied in Phase I/II clinical trials. Preliminary results 
      demonstrate that generation of a vaccine is feasible and that vaccination is 
      associated with minimal toxicity. Immunological and clinical responses have been 
      found in a subset of patients.
FAU - Rosenblatt, Jacalyn
AU  - Rosenblatt J
AD  - Hematologic Malignancy Bone Marrow Transplant Program, Beth Israel Deaconess 
      Medical Center, 330 Brookline Avenue, KS 121, Boston, MA 02215, USA. 
      jacalyn_rosenblatt@bidmc.harvard.edu
FAU - Kufe, Donald
AU  - Kufe D
FAU - Avigan, David
AU  - Avigan D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Cancer Vaccines/*immunology/metabolism
MH  - Cell Fusion/methods
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Immunotherapy/*methods
MH  - Neoplasms/*immunology/metabolism
RF  - 114
EDAT- 2005/06/07 09:00
MHDA- 2006/04/07 09:00
CRDT- 2005/06/07 09:00
PHST- 2005/06/07 09:00 [pubmed]
PHST- 2006/04/07 09:00 [medline]
PHST- 2005/06/07 09:00 [entrez]
AID - 10.1517/14712598.5.5.703 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2005 May;5(5):703-15. doi: 10.1517/14712598.5.5.703.